SC68896, a Novel Small Molecule Proteasome Inhibitor, Exerts Antiglioma Activity In vitro and In vivo

Purpose: Glioblastomas are among the most lethal neoplasms, with a median survival of

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Bibliographic Details
Published in:Clinical cancer research 2009-11, Vol.15 (21), p.6609-6618
Main Authors: Roth, Patrick, Kissel, Maria, Herrmann, Caroline, Eisele, Günter, Leban, Johann, Weller, Michael, Schmidt, Friederike
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - therapeutic use
apoptosis
Brain Neoplasms - drug therapy
Cell Cycle - drug effects
Cell Line, Tumor
Cell Proliferation - drug effects
Fas Ligand Protein - metabolism
glioma
Glioma - drug therapy
Humans
Mice
Mice, Nude
p53
proteasome
Proteasome Inhibitors
Semicarbazones - therapeutic use
TNF-Related Apoptosis-Inducing Ligand - metabolism
TRAIL
Xenograft Model Antitumor Assays
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Description
Summary:Purpose: Glioblastomas are among the most lethal neoplasms, with a median survival of
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.CCR-09-0548