Host Single Nucleotide Polymorphisms of MMP-9 −1562/TIMP-1 372 Have Gender Differences in the Risk of Gastric Intestinal Metaplasia After Helicobacter pylori Infection

Background:  Helicobacter pylori infection causes chronic gastric inflammation and intestinal metaplasia (IM), related with deregulation of Wnt pathway and over‐expressions of COX‐2, matrix metalloproteinase (MMP), and tissue inhibitors of matrix metalloproteinase (TIMP). We thus test the host genom...

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Published in:Helicobacter (Cambridge, Mass.) Mass.), 2009-12, Vol.14 (6), p.580-587
Main Authors: Hung, Kuei-Hsiang, Hung, Hunt-Wen, Yang, Hsiao-Bai, Lu, Cheng-Chan, Wu, Jiunn-Jong, Sheu, Bor-Shyang
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Genetic Predisposition to Disease
H. pylori
Helicobacter Infections - genetics
Helicobacter Infections - immunology
Helicobacter Infections - microbiology
Helicobacter Infections - pathology
Helicobacter pylori - physiology
Humans
intestinal metaplasia
Intestines - immunology
Intestines - pathology
Male
Matrix Metalloproteinase 9 - genetics
Metaplasia - genetics
Metaplasia - immunology
Metaplasia - microbiology
Metaplasia - pathology
Middle Aged
MMP-9
Polymorphism, Single Nucleotide
Risk Factors
Sex Characteristics
Stomach - immunology
Stomach - pathology
TIMP-1
Tissue Inhibitor of Metalloproteinase-1 - genetics
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Summary:Background:  Helicobacter pylori infection causes chronic gastric inflammation and intestinal metaplasia (IM), related with deregulation of Wnt pathway and over‐expressions of COX‐2, matrix metalloproteinase (MMP), and tissue inhibitors of matrix metalloproteinase (TIMP). We thus test the host genomic predispositions related to the risk of IM after H. pylori infection. Methods:  We enrolled 296 H. pylori‐infected patients to provide gastric biopsies for histology and genomic DNA for genotypes of single nucleotide polymorphisms (SNPs), including APC, COX‐2, IL‐1B, IL‐1RN, IL‐10, MMP‐2, MMP‐9, TIMP‐1, and TIMP‐2 determined by sequence specific oligonucleotide probe, sequence specific primers, restriction fragment length polymorphism, or real‐time polymerase chain reaction. Results:  There was no association between the presence of IM and SNPs in APC, COX‐2, IL‐1B, IL‐1RN, IL‐10, MMP‐2, and TIMP‐2. The risk of IM was increased up to 2.29‐folds in males with TIMP‐1 372 C, and 3.03‐fold in females with T carrier (p 
ISSN:1083-4389
1523-5378
DOI:10.1111/j.1523-5378.2009.00717.x