Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures

Background: Antiepileptic and neuroprotective effects of melatonin (N-acetyl-5-methoxytryptamine) have been shown at higher doses (50-160 mg/kg). We aimed to investigate the antiepileptic effects of low-dose melatonin (10 mg/kg) on pentylenetetrazol (PTZ)-induced experimental epilepsy model. Materia...

Full description

Saved in:
Bibliographic Details
Published in:Neurological research (New York) 2009-11, Vol.31 (9), p.989-995
Main Authors: Solmaz, Ilker, Gurkanlar, Doga, Gokcil, Zeki, Goksoy, Cuneyt, Ozkan, Muhip, Erdogan, Ersin
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - metabolism
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
Brain - drug effects
Brain - metabolism
Brain - physiopathology
Central Nervous System Depressants - pharmacology
Convulsants - pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Interactions - physiology
ELECTROENCEPHALOGRAPHY
EPILEPSY
Epilepsy - chemically induced
Epilepsy - drug therapy
Epilepsy - physiopathology
Ethanol - pharmacology
GUINEA PIG
Guinea Pigs
Male
MELATONIN
Melatonin - metabolism
Melatonin - pharmacology
Melatonin - therapeutic use
Neuroprotective Agents - metabolism
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
PENTYLENETETRAZOL
Pentylenetetrazole - pharmacology
STEREOTAXY
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Antiepileptic and neuroprotective effects of melatonin (N-acetyl-5-methoxytryptamine) have been shown at higher doses (50-160 mg/kg). We aimed to investigate the antiepileptic effects of low-dose melatonin (10 mg/kg) on pentylenetetrazol (PTZ)-induced experimental epilepsy model. Materials and Methods: Twelve male albino guinea pigs weighing 500-800 g were used in our work. Initially, latent period, seizure intensity and mortality parameters were evaluated during the epileptic seizure induced by PTZ. After a recovery period of 7 days, effects of the neuroprotective agent, melatonin (which is dissolved in 2.5% ethanol-saline solution), on epileptic seizures induced by PTZ were evaluated. Effects of 2.5% ethanol, which is an anticonvulsant agent when administered acutely in high concentrations, on PTZ-induced seizures were also evaluated. Results: Data obtained from the study groups (PTZ, PTZ + melatonin and PTZ + ethanol) were evaluated by paired t-test, and p
ISSN:0161-6412
1743-1328
DOI:10.1179/174313209X385545