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Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures
Background: Antiepileptic and neuroprotective effects of melatonin (N-acetyl-5-methoxytryptamine) have been shown at higher doses (50-160 mg/kg). We aimed to investigate the antiepileptic effects of low-dose melatonin (10 mg/kg) on pentylenetetrazol (PTZ)-induced experimental epilepsy model. Materia...
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| Published in: | Neurological research (New York) 2009-11, Vol.31 (9), p.989-995 |
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| container_issue | 9 |
| container_start_page | 989 |
| container_title | Neurological research (New York) |
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| creator | Solmaz, Ilker Gurkanlar, Doga Gokcil, Zeki Goksoy, Cuneyt Ozkan, Muhip Erdogan, Ersin |
| description | Background: Antiepileptic and neuroprotective effects of melatonin (N-acetyl-5-methoxytryptamine) have been shown at higher doses (50-160 mg/kg). We aimed to investigate the antiepileptic effects of low-dose melatonin (10 mg/kg) on pentylenetetrazol (PTZ)-induced experimental epilepsy model.
Materials and Methods: Twelve male albino guinea pigs weighing 500-800 g were used in our work. Initially, latent period, seizure intensity and mortality parameters were evaluated during the epileptic seizure induced by PTZ. After a recovery period of 7 days, effects of the neuroprotective agent, melatonin (which is dissolved in 2.5% ethanol-saline solution), on epileptic seizures induced by PTZ were evaluated. Effects of 2.5% ethanol, which is an anticonvulsant agent when administered acutely in high concentrations, on PTZ-induced seizures were also evaluated.
Results: Data obtained from the study groups (PTZ, PTZ + melatonin and PTZ + ethanol) were evaluated by paired t-test, and p |
| doi_str_mv | 10.1179/174313209X385545 |
| format | article |
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Materials and Methods: Twelve male albino guinea pigs weighing 500-800 g were used in our work. Initially, latent period, seizure intensity and mortality parameters were evaluated during the epileptic seizure induced by PTZ. After a recovery period of 7 days, effects of the neuroprotective agent, melatonin (which is dissolved in 2.5% ethanol-saline solution), on epileptic seizures induced by PTZ were evaluated. Effects of 2.5% ethanol, which is an anticonvulsant agent when administered acutely in high concentrations, on PTZ-induced seizures were also evaluated.
Results: Data obtained from the study groups (PTZ, PTZ + melatonin and PTZ + ethanol) were evaluated by paired t-test, and p<0.005 was considered statistically significant. The differences of latent periods between the PTZ and PTZ + melatonin groups were found to be statistically significant (p<0.001).
Conclusion: Although melatonin does not have a primary anticonvulsant effect at low doses (10 mg/kg), it lowers the mortality rates and attenuates seizure severity while increasing the latent period.</description><identifier>ISSN: 0161-6412</identifier><identifier>EISSN: 1743-1328</identifier><identifier>DOI: 10.1179/174313209X385545</identifier><identifier>PMID: 19138464</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animals ; Anticonvulsants - metabolism ; Anticonvulsants - pharmacology ; Anticonvulsants - therapeutic use ; Brain - drug effects ; Brain - metabolism ; Brain - physiopathology ; Central Nervous System Depressants - pharmacology ; Convulsants - pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Interactions - physiology ; ELECTROENCEPHALOGRAPHY ; EPILEPSY ; Epilepsy - chemically induced ; Epilepsy - drug therapy ; Epilepsy - physiopathology ; Ethanol - pharmacology ; GUINEA PIG ; Guinea Pigs ; Male ; MELATONIN ; Melatonin - metabolism ; Melatonin - pharmacology ; Melatonin - therapeutic use ; Neuroprotective Agents - metabolism ; Neuroprotective Agents - pharmacology ; Neuroprotective Agents - therapeutic use ; PENTYLENETETRAZOL ; Pentylenetetrazole - pharmacology ; STEREOTAXY ; Time Factors</subject><ispartof>Neurological research (New York), 2009-11, Vol.31 (9), p.989-995</ispartof><rights>2009 Maney Publishing 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-569ca563b2b0468129391162336a1b86768f141e03e7e7f65d8cd4b384aac1913</citedby><cites>FETCH-LOGICAL-c406t-569ca563b2b0468129391162336a1b86768f141e03e7e7f65d8cd4b384aac1913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19138464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Solmaz, Ilker</creatorcontrib><creatorcontrib>Gurkanlar, Doga</creatorcontrib><creatorcontrib>Gokcil, Zeki</creatorcontrib><creatorcontrib>Goksoy, Cuneyt</creatorcontrib><creatorcontrib>Ozkan, Muhip</creatorcontrib><creatorcontrib>Erdogan, Ersin</creatorcontrib><title>Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures</title><title>Neurological research (New York)</title><addtitle>Neurol Res</addtitle><description>Background: Antiepileptic and neuroprotective effects of melatonin (N-acetyl-5-methoxytryptamine) have been shown at higher doses (50-160 mg/kg). We aimed to investigate the antiepileptic effects of low-dose melatonin (10 mg/kg) on pentylenetetrazol (PTZ)-induced experimental epilepsy model.
Materials and Methods: Twelve male albino guinea pigs weighing 500-800 g were used in our work. Initially, latent period, seizure intensity and mortality parameters were evaluated during the epileptic seizure induced by PTZ. After a recovery period of 7 days, effects of the neuroprotective agent, melatonin (which is dissolved in 2.5% ethanol-saline solution), on epileptic seizures induced by PTZ were evaluated. Effects of 2.5% ethanol, which is an anticonvulsant agent when administered acutely in high concentrations, on PTZ-induced seizures were also evaluated.
Results: Data obtained from the study groups (PTZ, PTZ + melatonin and PTZ + ethanol) were evaluated by paired t-test, and p<0.005 was considered statistically significant. The differences of latent periods between the PTZ and PTZ + melatonin groups were found to be statistically significant (p<0.001).
Conclusion: Although melatonin does not have a primary anticonvulsant effect at low doses (10 mg/kg), it lowers the mortality rates and attenuates seizure severity while increasing the latent period.</description><subject>Animals</subject><subject>Anticonvulsants - metabolism</subject><subject>Anticonvulsants - pharmacology</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain - physiopathology</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Convulsants - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Interactions - physiology</subject><subject>ELECTROENCEPHALOGRAPHY</subject><subject>EPILEPSY</subject><subject>Epilepsy - chemically induced</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - physiopathology</subject><subject>Ethanol - pharmacology</subject><subject>GUINEA PIG</subject><subject>Guinea Pigs</subject><subject>Male</subject><subject>MELATONIN</subject><subject>Melatonin - metabolism</subject><subject>Melatonin - pharmacology</subject><subject>Melatonin - therapeutic use</subject><subject>Neuroprotective Agents - metabolism</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>PENTYLENETETRAZOL</subject><subject>Pentylenetetrazole - pharmacology</subject><subject>STEREOTAXY</subject><subject>Time Factors</subject><issn>0161-6412</issn><issn>1743-1328</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kEFLHTEUhYNU9Gndu5JZ1dXU3CSTyeBKxNaC4EahdDNkMndsSiaZJhnl-es7j_dAKChcuHD4zuHeQ8gp0K8AdXMBteDAGW1-clVVotojq41ULpr6RFYUJJRSADskRyn9oRQappoDcggNcCWkWJFfVz5bnKzDKVtTaJPts83rIgzFiE7n4K0vlnmarUddTPYpFS82_y4m9Hnt0GPGHPVrcKX1_WywLxLa1zli-kz2B-0Snuz2MXn8dvNwfVve3X__cX11VxpBZS4r2RhdSd6xjgqpgDW8AZCMc6mhU7KWagABSDnWWA-y6pXpRbfcr7XZPHJMzre5Uwx_Z0y5HW0y6Jz2GObU1nxpoGayWsgvH5IMGFNA5QLSLWhiSCni0E7RjjquW6Dtpvn2_-YXy9kue-5G7N8Mu6oX4HILWD-EOOqXEF3fZr12IQ5Re2NTy9-N_wd_ZpE2</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Solmaz, Ilker</creator><creator>Gurkanlar, Doga</creator><creator>Gokcil, Zeki</creator><creator>Goksoy, Cuneyt</creator><creator>Ozkan, Muhip</creator><creator>Erdogan, Ersin</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures</title><author>Solmaz, Ilker ; Gurkanlar, Doga ; Gokcil, Zeki ; Goksoy, Cuneyt ; Ozkan, Muhip ; Erdogan, Ersin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-569ca563b2b0468129391162336a1b86768f141e03e7e7f65d8cd4b384aac1913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Anticonvulsants - metabolism</topic><topic>Anticonvulsants - pharmacology</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain - physiopathology</topic><topic>Central Nervous System Depressants - pharmacology</topic><topic>Convulsants - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Interactions - physiology</topic><topic>ELECTROENCEPHALOGRAPHY</topic><topic>EPILEPSY</topic><topic>Epilepsy - chemically induced</topic><topic>Epilepsy - drug therapy</topic><topic>Epilepsy - physiopathology</topic><topic>Ethanol - pharmacology</topic><topic>GUINEA PIG</topic><topic>Guinea Pigs</topic><topic>Male</topic><topic>MELATONIN</topic><topic>Melatonin - metabolism</topic><topic>Melatonin - pharmacology</topic><topic>Melatonin - therapeutic use</topic><topic>Neuroprotective Agents - metabolism</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>PENTYLENETETRAZOL</topic><topic>Pentylenetetrazole - pharmacology</topic><topic>STEREOTAXY</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solmaz, Ilker</creatorcontrib><creatorcontrib>Gurkanlar, Doga</creatorcontrib><creatorcontrib>Gokcil, Zeki</creatorcontrib><creatorcontrib>Goksoy, Cuneyt</creatorcontrib><creatorcontrib>Ozkan, Muhip</creatorcontrib><creatorcontrib>Erdogan, Ersin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurological research (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solmaz, Ilker</au><au>Gurkanlar, Doga</au><au>Gokcil, Zeki</au><au>Goksoy, Cuneyt</au><au>Ozkan, Muhip</au><au>Erdogan, Ersin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures</atitle><jtitle>Neurological research (New York)</jtitle><addtitle>Neurol Res</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>31</volume><issue>9</issue><spage>989</spage><epage>995</epage><pages>989-995</pages><issn>0161-6412</issn><eissn>1743-1328</eissn><abstract>Background: Antiepileptic and neuroprotective effects of melatonin (N-acetyl-5-methoxytryptamine) have been shown at higher doses (50-160 mg/kg). We aimed to investigate the antiepileptic effects of low-dose melatonin (10 mg/kg) on pentylenetetrazol (PTZ)-induced experimental epilepsy model.
Materials and Methods: Twelve male albino guinea pigs weighing 500-800 g were used in our work. Initially, latent period, seizure intensity and mortality parameters were evaluated during the epileptic seizure induced by PTZ. After a recovery period of 7 days, effects of the neuroprotective agent, melatonin (which is dissolved in 2.5% ethanol-saline solution), on epileptic seizures induced by PTZ were evaluated. Effects of 2.5% ethanol, which is an anticonvulsant agent when administered acutely in high concentrations, on PTZ-induced seizures were also evaluated.
Results: Data obtained from the study groups (PTZ, PTZ + melatonin and PTZ + ethanol) were evaluated by paired t-test, and p<0.005 was considered statistically significant. The differences of latent periods between the PTZ and PTZ + melatonin groups were found to be statistically significant (p<0.001).
Conclusion: Although melatonin does not have a primary anticonvulsant effect at low doses (10 mg/kg), it lowers the mortality rates and attenuates seizure severity while increasing the latent period.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>19138464</pmid><doi>10.1179/174313209X385545</doi><tpages>7</tpages></addata></record> |
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| ispartof | Neurological research (New York), 2009-11, Vol.31 (9), p.989-995 |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Animals Anticonvulsants - metabolism Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Brain - drug effects Brain - metabolism Brain - physiopathology Central Nervous System Depressants - pharmacology Convulsants - pharmacology Disease Models, Animal Dose-Response Relationship, Drug Drug Interactions - physiology ELECTROENCEPHALOGRAPHY EPILEPSY Epilepsy - chemically induced Epilepsy - drug therapy Epilepsy - physiopathology Ethanol - pharmacology GUINEA PIG Guinea Pigs Male MELATONIN Melatonin - metabolism Melatonin - pharmacology Melatonin - therapeutic use Neuroprotective Agents - metabolism Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use PENTYLENETETRAZOL Pentylenetetrazole - pharmacology STEREOTAXY Time Factors |
| title | Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures |
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