Effect of Collagen Hydrolysates from Salmon and Trout Skins on the Lipid Profile in Rats

The effect of collagen hydrolysates from fish skins on lipid profile was assessed in rats administered chum salmon or rainbow trout collagen peptide. Single oral administration of soybean oil with or without one of either type of fish collagen peptide demonstrated that rat plasma triglycerides were...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2009-11, Vol.57 (21), p.10477-10482
Main Authors: Saito, Masataka, Kiyose, Chikako, Higuchi, Tomoyuki, Uchida, Naoyuki, Suzuki, Hiramitsu
Format: Article
Language:English
Subjects:
animal models
Animals
Biological and medical sciences
blood lipids
Body Weight - drug effects
collagen
Collagen - chemistry
Collagen - pharmacology
collagen hydrolysates
Fish and seafood industries
Fish Proteins - chemistry
Fish Proteins - pharmacology
fish waste
Food industries
Fundamental and applied biological sciences. Psychology
hydrolysates
Hydrolysis
lipid metabolism
Lipids - blood
Male
Molecular Nutrition
Organ Size - drug effects
Peptides - chemistry
Peptides - pharmacology
Random Allocation
Rats
Rats, Sprague-Dawley
salmon
Salmon - metabolism
skin
Skin - chemistry
Triglycerides - blood
trout
Trout - metabolism
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Summary:The effect of collagen hydrolysates from fish skins on lipid profile was assessed in rats administered chum salmon or rainbow trout collagen peptide. Single oral administration of soybean oil with or without one of either type of fish collagen peptide demonstrated that rat plasma triglycerides were significantly decreased 2 h later after the intake of oil and peptide mixtures (p < 0.05). The free and peptide forms of hydroxyproline derived from fish collagen peptides were statistically higher than those of zero time after oral administration. To test the effect of fish collagen peptides on continuous administration, rats were fed an AIN-93G purified diet containing 0.17% fish collagen peptide. The peptide groups had lower levels of plasma total lipids and triglycerides compared with the control group. However, the body, liver, and fat weights of rats were not significantly different between groups. These results suggest that fish collagen hydrolysates affect lipid absorption and metabolism in rats and may be useful in suppressing the transient increase of plasma triglycerides.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf902355m