Lichenoid drug eruption

A 78-year-old man presented with an eight-month history of folliculocentric, pink, hyperkeratotic papules and plaques with thick white scale that involved the entire body, with confluence on the buttocks and genitalia. A biopsy specimen demonstrated superficial and focal, mild perivascular and perif...

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Bibliographic Details
Published in:Dermatology online journal 2009-08, Vol.15 (8), p.13-13
Main Authors: Brauer, Jeremy, Votava, Henry J, Meehan, Shane, Soter, Nicholas A
Format: Article
Language:English
Subjects:
Aged
Drug Eruptions - etiology
Drug Eruptions - pathology
Humans
Lichenoid Eruptions - chemically induced
Lichenoid Eruptions - pathology
Male
Omeprazole - adverse effects
Proton Pump Inhibitors - adverse effects
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Summary:A 78-year-old man presented with an eight-month history of folliculocentric, pink, hyperkeratotic papules and plaques with thick white scale that involved the entire body, with confluence on the buttocks and genitalia. A biopsy specimen demonstrated superficial and focal, mild perivascular and perifollicular, band-like lymphocytic infiltrate and eosinophils. There were lymphocytes extending to the dermo-epidermal junction with vacuolar changes. A diagnosis of lichenoid drug eruption secondary to a proton-pump inhibitor was made. To the best of our knowledge, only one other case of lichenoid drug eruption secondary to a proton-pump inhibitor has been reported.
ISSN:1087-2108
1087-2108
DOI:10.5070/D335C1029X