Metabolic Syndrome Is Associated with Intracranial Large Artery Disease among Ethnic Chinese Patients with Stroke

Background The association of metabolic syndrome (MetS) and intracranial large artery disease (ICLAD) has been described, but only in cohorts of ethnic Korean patients with stroke. We investigated the relationship of MetS and ICLAD among ethnic Chinese patients. Methods This is a prospective study o...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2009-11, Vol.18 (6), p.424-427
Main Authors: De Silva, Deidre Anne, MBBS, MRCP, Woon, Fung-Peng, MSc, Lee, Moi-Pin, RVT, Chen, Christopher Li-Hsian, MRCP, FAMS, Chang, Hui-Meng, MBBS, MRCP, Wong, Meng-Cheong, MBBS, MRCP
Format: Article
Language:English
Subjects:
Aged
Asian Continental Ancestry Group
Brain Ischemia - ethnology
Brain Ischemia - etiology
Cardiovascular
Cerebral Angiography
China - ethnology
Cross-Sectional Studies
ethnic Chinese
Female
Humans
Intracranial Arterial Diseases - complications
Intracranial Arterial Diseases - diagnosis
Intracranial Arterial Diseases - ethnology
intracranial large artery disease
Magnetic Resonance Angiography
Male
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - ethnology
Middle Aged
Neurology
Prevalence
Prospective Studies
Risk Factors
Singapore - epidemiology
stroke
Stroke - ethnology
Stroke - etiology
Ultrasonography, Doppler, Color
Ultrasonography, Doppler, Transcranial
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Summary:Background The association of metabolic syndrome (MetS) and intracranial large artery disease (ICLAD) has been described, but only in cohorts of ethnic Korean patients with stroke. We investigated the relationship of MetS and ICLAD among ethnic Chinese patients. Methods This is a prospective study of consecutive ethnic Chinese patients with acute ischemic stroke living in Singapore. ICLAD was diagnosed on transcranial color-coded Doppler or magnetic resonance angiography. Results Among the 135 patients studied, the frequency of MetS was higher among patients with ICLAD (39% v 16%, P = .003). This association was independent of age, hypertension, and diabetes ( P = .003), and individual MetS criteria ( P = .004). The prevalence of ICLAD positively correlated with the number of MetS criteria fulfilled ( P = .021). Conclusions Our findings of an association between MetS and ICLAD among ethnic Chinese patients with stroke concur with findings among ethnic Korean patients. This validation provides a basis for further investigation into the pathophysiologic link between MetS and ICLAD.
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2009.01.010