NO-Positive Neurons in Some Nuclei of Human Bulbar Vasomotor Center in Arterial Hypertension

The distribution of nitroxidergic neurons and activities of neuronal NO synthase in them in some nuclei of the bulbar vasomotor center were studied in patients with early forms of arterial hypertension. Activity of neuronal NO synthase is reduced significantly in the majority of nuclei in patients w...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2009-05, Vol.147 (5), p.639-643
Main Authors: Chertok, V. M, Kotsyuba, A. E
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomedical and Life Sciences
Biomedicine
bulbar vasomotor center
Cell Biology
Cell Nucleus - metabolism
Cell Nucleus - pathology
Humans
hypertension
Hypertension - physiopathology
Internal Medicine
Laboratory Medicine
Male
Morphology and Pathomorphology
NADP - metabolism
Nitrergic Neurons - cytology
Nitrergic Neurons - enzymology
Nitric Oxide Synthase - metabolism
nitroxidergic neurons
Pathology
Vasomotor System - cytology
Vasomotor System - metabolism
Vasomotor System - pathology
Young Adult
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Description
Summary:The distribution of nitroxidergic neurons and activities of neuronal NO synthase in them in some nuclei of the bulbar vasomotor center were studied in patients with early forms of arterial hypertension. Activity of neuronal NO synthase is reduced significantly in the majority of nuclei in patients with early forms of arterial hypertension, while the content of NO-positive cells was only slightly changed. More pronounced changes in this parameter were detected in the solitary tract nuclei in comparison with the reticular formation nuclei, which had efferent relationships with the intermediate lateral spinal nucleus.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0560-9