Interspecies Spread of Klebsiella pneumoniae Carbapenemase Gene in a Single Patient

Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae, Escherichia coli, and Serratia marcescens were sequentially identified in a patient who underwent small bowel transplantation. Molecular typing and plasmid analysis suggested that the KPC gene was acquired by E. coli, most likely fro...

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Bibliographic Details
Published in:Clinical infectious diseases 2009-12, Vol.49 (11), p.1736-1738
Main Authors: Sidjabat, Hanna E., Silveira, Fernanda P., Potoski, Brian A., Abu-Elmagd, Kareem M., Adams-Haduch, Jennifer M., Paterson, David L., Doi, Yohei
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - therapeutic use
Antibiotics
Bacteremia
Bacterial Proteins - genetics
beta-Lactamases - genetics
Biological and medical sciences
BRIEF REPORTS
Carbapenems
Carbapenems - therapeutic use
Drug Resistance, Bacterial - genetics
E coli
Enterobacteriaceae
Escherichia coli
Escherichia coli - genetics
Female
Gene Transfer, Horizontal - genetics
Genes
Humans
Infectious diseases
Klebsiella Infections - drug therapy
Klebsiella Infections - microbiology
Klebsiella pneumoniae
Klebsiella pneumoniae - enzymology
Klebsiella pneumoniae - genetics
Medical sciences
Plasmids
Plasmids - genetics
Polymerase Chain Reaction
Serratia marcescens
Serratia marcescens - genetics
Transplants & implants
Transposons
Citations: Items that cite this one
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Description
Summary:Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae, Escherichia coli, and Serratia marcescens were sequentially identified in a patient who underwent small bowel transplantation. Molecular typing and plasmid analysis suggested that the KPC gene was acquired by E. coli, most likely from K. pneumoniae, and was subsequently transferred to S. marcescens .
ISSN:1058-4838
1537-6591
DOI:10.1086/648077