Successful perinatal outcome in an early onset intrahepatic cholestasis of pregnancy with extremely high serum hepatic function tests

We report a case of a 21-year-old pregnant woman with an early onset of intrahepatic cholestasis of pregnancy with very high aminotransferases activity and bilirubin concentration. Viral and autoimmune hepatitis, and other possible causes of liver function impairment were excluded. Treatment with ur...

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Bibliographic Details
Published in:Gynecological endocrinology 2009-07, Vol.25 (7), p.475-476
Main Authors: Smolarczyk, Roman, Grymowicz, Monika, Sienko, Jacek, Czajkowski, Krzysztof
Format: Article
Language:English
Subjects:
Alanine Transaminase - blood
Alkaline Phosphatase - blood
Aspartate Aminotransferases - blood
Bilirubin - blood
Cholestasis
Cholestasis, Intrahepatic - etiology
Cholestasis, Intrahepatic - metabolism
Female
Humans
Infant, Newborn
liver
Liver Function Tests
perinatal outcome
Pregnancy
Pregnancy Complications - metabolism
Pregnancy Outcome
Severity of Illness Index
ursodeoxycholic acid
Young Adult
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Summary:We report a case of a 21-year-old pregnant woman with an early onset of intrahepatic cholestasis of pregnancy with very high aminotransferases activity and bilirubin concentration. Viral and autoimmune hepatitis, and other possible causes of liver function impairment were excluded. Treatment with ursodeoxycholic acid improved biochemical markers. The patient delivered a healthy female neonate by caesarean section. Neonatal and postoperative courses were uneventful.
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590902945147