The effect of atorvastatin on serum lipids, lipoproteins and NMR spectroscopy defined lipoprotein subclasses in type 2 diabetic patients with ischaemic heart disease

The effect of statin therapy on subclasses of LDL, VLDL and HDL lipoproteins is unclear. We compared changes in serum lipids, apolipoproteins and nuclear magnetic resonance (NMR) spectroscopy measured lipoprotein subclass concentration and average particle size over a minimum 6 months treatment peri...

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Bibliographic Details
Published in:Atherosclerosis 2003-04, Vol.167 (2), p.243-255
Main Authors: Soedamah-Muthu, S.S., Colhoun, H.M., Thomason, M.J., Betteridge, D.J., Durrington, P.N., Hitman, G.A., Fuller, J.H., Julier, K., Mackness, M.I., Neil, H.A.W.
Format: Article
Language:English
Subjects:
Aged
Atorvastatin
Biological and medical sciences
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnosis
Double-Blind Method
Female
General and cellular metabolism. Vitamins
Heptanoic Acids - administration & dosage
HMG-CoA reductase inhibitors
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
Hyperlipidemias - complications
Hyperlipidemias - diagnosis
Hyperlipidemias - drug therapy
Lipoprotein subclasses
Lipoproteins, HDL - blood
Lipoproteins, HDL - drug effects
Lipoproteins, LDL - blood
Lipoproteins, LDL - drug effects
Lipoproteins, VLDL - blood
Lipoproteins, VLDL - drug effects
Magnetic Resonance Spectroscopy
Male
Medical sciences
Middle Aged
Myocardial Ischemia - complications
Myocardial Ischemia - diagnosis
Myocardial Ischemia - drug therapy
NMR spectroscopy
Patient Compliance
Pharmacology. Drug treatments
Probability
Pyrroles - administration & dosage
Reference Values
Risk Assessment
Treatment Outcome
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Summary:The effect of statin therapy on subclasses of LDL, VLDL and HDL lipoproteins is unclear. We compared changes in serum lipids, apolipoproteins and nuclear magnetic resonance (NMR) spectroscopy measured lipoprotein subclass concentration and average particle size over a minimum 6 months treatment period of atorvastatin 10 mg vs. placebo in 122 men and women. All subjects had type 2 diabetes and a modest dyslipidaemia (mean LDL-cholesterol 3.2 mmol/l and median triglycerides 1.8 mmol/l) and had a previous myocardial infarction. Compared with placebo, atorvastatin therapy was associated with a greater decrease in medium VLDL (median within person change −13.4 vs. −5.9 nmol/l, P
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(02)00428-8