Pax-3 and Pax-7 Label Muscle Progenitor Cells During Myotomal Myogenesis in Coregonus lavaretus (Teleostei: Coregonidae)

In Coregonus lavaretus, prior the mesoderm segmentation, in cells adjacent to the notochord called adaxial cells MyoD and slow myosin heavy chain (MyHC-slow) proteins were observed. After somite formation, adaxial cells migrate towards the lateral part of the myotome and form a layer of red muscles....

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Bibliographic Details
Published in:Anatomia, histologia, embryologia histologia, embryologia, 2009-12, Vol.38 (6), p.411-418
Main Authors: Kacperczyk, A, Jagla, T, Daczewska, M
Format: Article
Language:English
Subjects:
Animals
Mesoderm - embryology
Muscle Development - physiology
Muscle Fibers, Fast-Twitch - physiology
Muscle Fibers, Skeletal
Muscle, Skeletal - embryology
Muscle, Skeletal - growth & development
Myoblasts - metabolism
MyoD Protein - metabolism
Myosin Heavy Chains - metabolism
Notochord - embryology
Paired Box Transcription Factors - genetics
Paired Box Transcription Factors - metabolism
PAX3 Transcription Factor
PAX7 Transcription Factor - genetics
PAX7 Transcription Factor - metabolism
Salmonidae - embryology
Salmonidae - metabolism
Satellite Cells, Skeletal Muscle - physiology
Somites - embryology
Zebrafish Proteins - genetics
Zebrafish Proteins - metabolism
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Summary:In Coregonus lavaretus, prior the mesoderm segmentation, in cells adjacent to the notochord called adaxial cells MyoD and slow myosin heavy chain (MyHC-slow) proteins were observed. After somite formation, adaxial cells migrate towards the lateral part of the myotome and form a layer of red muscles. Deeper cells differentiate into white muscle fibres. In situ hybridization using Pax-3 molecular probe revealed, that after somitogenesis, Pax-3 is expressed in a layer of cells superficial to the myotome resembling the "external cells" (found in many teleosts species) or dermomyotome described in Amniota. During later developmental stages Pax-3 gene is expressed in cells in intermyotomal space and then in myoblasts between myotubes. In these cells Pax-7 protein was also observed. Pax-3/7 positive cells which have migrated into the myotomes differentiate into satellite cells/secondary myoblasts and participate in hypertrophic and hyperplastic growth of muscles.
ISSN:0340-2096
1439-0264
DOI:10.1111/j.1439-0264.2009.00961.x