Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory

Acquired memory initially depends on the hippocampus (HPC) for the process of cortical permanent memory formation. The mechanisms through which memory becomes progressively independent from the HPC remain unknown. In the HPC, adult neurogenesis has been described in many mammalian species, even at o...

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Bibliographic Details
Published in:Cell 2009-11, Vol.139 (4), p.814-827
Main Authors: Kitamura, Takashi, Saitoh, Yoshito, Takashima, Noriko, Murayama, Akiko, Niibori, Yosuke, Ageta, Hiroshi, Sekiguchi, Mariko, Sugiyama, Hiroyuki, Inokuchi, Kaoru
Format: Article
Language:English
Subjects:
Animals
Conditioning, Classical
Dentate Gyrus - physiology
Fear - physiology
Follistatin - pharmacology
Hippocampus - cytology
Hippocampus - physiology
Hippocampus - radiation effects
Long-Term Potentiation - radiation effects
Mice
MOLNEURO
Neurogenesis - drug effects
Neurogenesis - radiation effects
Rats
X-Rays
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Summary:Acquired memory initially depends on the hippocampus (HPC) for the process of cortical permanent memory formation. The mechanisms through which memory becomes progressively independent from the HPC remain unknown. In the HPC, adult neurogenesis has been described in many mammalian species, even at old ages. Using two mouse models in which hippocampal neurogenesis is physically or genetically suppressed, we show that decreased neurogenesis is accompanied by a prolonged HPC-dependent period of associative fear memory. Inversely, enhanced neurogenesis by voluntary exercise sped up the decay rate of HPC dependency of memory, without loss of memory. Consistently, decreased neurogenesis facilitated the long-lasting maintenance of rat hippocampal long-term potentiation in vivo. These independent lines of evidence strongly suggest that the level of hippocampal neurogenesis play a role in determination of the HPC-dependent period of memory in adult rodents. These observations provide a framework for understanding the mechanisms of the hippocampal-cortical complementary learning systems.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2009.10.020