Inhibition of C5-cytosine-DNA-methyltransferases

Changes in the methylation pattern of genomic DNA, particularly hypermethylation of tumor suppressor genes, occur at early stages of tumor development. Errors in DNA methylation contribute to both initiation and progression of various cancers. This stimulates significant interest in searching for in...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2009-11, Vol.74 (11), p.1175-1186
Main Authors: Kirsanova, O. V., Cherepanova, N. A., Gromova, E. S.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cancer
Deoxyribonucleic acid
DNA
DNA Methylation
DNA-Cytosine Methylases - antagonists & inhibitors
DNA-Cytosine Methylases - chemistry
DNA-Cytosine Methylases - metabolism
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - therapeutic use
Genomics
Humans
Inhibitor drugs
Life Sciences
Microbiology
Neoplasms - drug therapy
Neoplasms - enzymology
Nucleosides - chemistry
Protein Binding
Review
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Summary:Changes in the methylation pattern of genomic DNA, particularly hypermethylation of tumor suppressor genes, occur at early stages of tumor development. Errors in DNA methylation contribute to both initiation and progression of various cancers. This stimulates significant interest in searching for inhibitors of C5-DNA-methyltransferases (MTases). Here we review the known nucleoside mechanism-based reversible and irreversible inhibitors of the MTases, as well as non-nucleoside ones, and discuss their inhibitory mechanisms and application for MTase investigations and cancer therapy.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297909110017