Squamous cell carcinoma of the nasal vestibule 1993-2002: A nationwide retrospective study from DAHANCA

Background. A retrospective nationwide study of cancer of the nasal vestibule was conducted to evaluate classification systems and prognostic factors for treatment outcome. Methods. Patients treated between 1993 and 2002 at head and neck oncology centers in Denmark were included. Results. The 5‐year...

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Published in:Head & neck 2009-12, Vol.31 (12), p.1593-1599
Main Authors: Agger, Andreas, von Buchwald, Christian, Madsen, Anders Rørbæk, Yde, Jesper, Lesnikova, Iana, Christensen, Charlotte Birk, Foghsgaard, Søren, Christensen, Thomas Broe, Hansen, Hanne Sand, Larsen, Susanne, Bentzen, Jens, Andersen, Elo, Andersen, Lisbeth, Grau, Cai
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Squamous Cell - classification
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Cohort Studies
Combined Modality Therapy
Denmark - epidemiology
Dermatology
Female
Follow-Up Studies
Humans
Male
Medical sciences
Nasal Cavity - pathology
Nasal Cavity - surgery
nasal vestibule
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Nose Neoplasms - classification
Nose Neoplasms - mortality
Nose Neoplasms - pathology
Nose Neoplasms - therapy
Otorhinolaryngology. Stomatology
Probability
Radiotherapy, Adjuvant
Reference Values
Registries
Retrospective Studies
Risk Assessment
smoking
squamous cell carcinoma
Survival Analysis
Survival Rate
Tobacco, tobacco smoking
Toxicology
treatment
Treatment Outcome
Tumors of the skin and soft tissue. Premalignant lesions
Wang
Wang, smoking
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Summary:Background. A retrospective nationwide study of cancer of the nasal vestibule was conducted to evaluate classification systems and prognostic factors for treatment outcome. Methods. Patients treated between 1993 and 2002 at head and neck oncology centers in Denmark were included. Results. The 5‐year results were locoregional control 67%, overall survival 50%, cancer‐specific survival 74%. Cancer‐specific survival according to Wang classification was 83%, 63%, and 39% for T1, T2, T3, respectively (p < .000). Regarding T1 tumors, 5‐year locoregional control for surgery, surgery + radiotherapy (RT), or RT was 94%, 87%, or 61%, respectively (p < .000). Fifty‐four Gray in 18 fractions was found comparable with 66 Gy in 33 fractions regarding T1 tumors. Conclusion. This national survey is the largest series of nasal vestibule cancer ever published. Wang classification is more prognostic and easier to use than the Union Internationale Contre le Cancer 2002. Surgery or hypofractionated RT can be used for T1 lesions, whereas larger lesions should be treated with combined approach. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.21132