Preservation of immune function and anti-hepatitis C virus (HCV) immune responses after liver transplantation in HIV–HCV coinfected patients (ANRS-HC08 “THEVIC” trial)

• Published in: Journal of hepatology 2009-12, Vol.51 (6), p.1000-1009
• Main Authors: Samri, Assia, Roque-Afonso, Anne-Marie, Beran, Ondrej, Tateo, Mariagrazia, Teicher, Elina, Feray, Cyrille, Sebagh, Mylène, Guettier, Catherine, Dussaix, Elisabeth, Vittecoq, Daniel, Samuel, Didier, Autran, Brigitte, Duclos-Vallée, Jean-Charles
• Format: Article
• Language: English
• Subjects: Adult; AIDS-Related Opportunistic Infections - immunology; Anti-HCV immune response; Anti-HCV therapy; Carcinoma, Hepatocellular - etiology; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - surgery; CD4 Lymphocyte Count; Female; Gastroenterology and Hepatology; HCV recurrence; Hepatitis C - complications; Hepatitis C - immunology; Hepatitis C - virology; Hepatitis C Antibodies - biosynthesis; HIV Core Protein p24 - immunology; HIV Infections - complications; HIV Infections - immunology; HIV–HCV coinfection; Humans; Immune Tolerance; In Vitro Techniques; Interferon-gamma - biosynthesis; Liver Cirrhosis - etiology; Liver Cirrhosis - immunology; Liver Cirrhosis - surgery; Liver Neoplasms - etiology; Liver Neoplasms - immunology; Liver Neoplasms - surgery; Liver transplantation; Liver Transplantation - immunology; Male; Middle Aged; T-Lymphocyte Subsets - immunology; Viral Load - immunology
• ISSN: 0168-8278; 1600-0641
• DOI: 10.1016/j.jhep.2009.06.031

Background/Aims Liver transplantation (LT) in immune-suppressed human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfected patients is feasible but raises questions regarding the severity of HCV recurrence on the liver graft and preservation of immune function. We investigated whether LT is deleterious to the immune system. Methods Fourteen HIV–HCV coinfected patients (HIV viral load [VL]