Patient Preference for Sustained-Release versus Standard Paracetamol (Acetaminophen): A Multicentre, Randomized, Open-Label, Two-Way Crossover Study in Subjects with Knee Osteoarthritis

Guidelines for osteoarthritis (OA) management recommend paracetamol (acetaminophen) as the most appropriate first-line analgesic for mild to moderate pain. Standard paracetamol requires four times daily dosing. Drug compliance and convenience are inversely related to daily dose frequency. Compliance...

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Bibliographic Details
Published in:Journal of international medical research 2009-09, Vol.37 (5), p.1321-1335
Main Authors: Benson, M, Marangou, A, Russo, MA, Durocher, J, Collaku, A, Starkey, YY
Format: Article
Language:English
Subjects:
Acetaminophen - therapeutic use
Administration, Oral
Adult
Aged
Aged, 80 and over
Analgesics, Non-Narcotic - therapeutic use
Cross-Over Studies
Dose-Response Relationship, Drug
Female
Humans
Male
Middle Aged
Osteoarthritis, Knee - drug therapy
Pain Measurement
Patient Preference
Tablets
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Summary:Guidelines for osteoarthritis (OA) management recommend paracetamol (acetaminophen) as the most appropriate first-line analgesic for mild to moderate pain. Standard paracetamol requires four times daily dosing. Drug compliance and convenience are inversely related to daily dose frequency. Compliance is a pivotal component of the successful management of OA pain and is influenced by patient preferences or beliefs. The added convenience of three times daily dosing may enhance compliance and, therefore, pain relief. This multicentre, randomized, open-label, two-way crossover, phase IV study is the first to evaluate patient preference with a sustained-release paracetamol tablet formulation designed for three times daily dosing. Compared with standard paracetamol tablets dosed four times daily, the sustained-release formulation was preferred in a 2:1 ratio, provided better overall joint pain relief, resulted in higher levels of satisfaction in subjects with OA of the knee and has the potential to improve patient compliance and, therefore, pain control.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323000903700507