Lack of Clinical Benefit of Improved Angiographic Results With Sirolimus-Eluting Stents Compared With Paclitaxel and Zotarolimus-Eluting Stents in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Background: There is limited information regarding the angiographic and clinical outcomes among the different drug-eluting stents (DESs) in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Methods and Results: A total 355 consecutive AMI patients w...

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Bibliographic Details
Published in:Circulation Journal 2009, Vol.73(12), pp.2229-2235
Main Authors: Choi, Cheol Ung, Rha, Seung-Woon, Chen, Kang-Yin, Li, Yong-Jian, Poddar, Kanhaiya L., Jin, Zhe, Minami, Yoshiyasu, Suh, Soon Yong, Na, Jin Oh, Lim, Hong Euy, Kim, Jin Won, Kim, Eung Ju, Park, Chang Gyu, Seo, Hong Seog, Oh, Dong Joo
Format: Article
Language:English
Subjects:
Acute myocardial infarction
Aged
Angioplasty, Balloon, Coronary - adverse effects
Angioplasty, Balloon, Coronary - instrumentation
Cardiovascular Agents - administration & dosage
Coronary Angiography
Coronary Restenosis - diagnostic imaging
Coronary Restenosis - etiology
Coronary Restenosis - prevention & control
Drug-Eluting Stents
Female
Humans
Logistic Models
Male
Middle Aged
Myocardial Infarction - diagnostic imaging
Myocardial Infarction - therapy
Odds Ratio
Paclitaxel - administration & dosage
Paclitaxel-eluting stents
Prosthesis Design
Registries
Retrospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index
Sirolimus - administration & dosage
Sirolimus - analogs & derivatives
Sirolimus-eluting stents
Treatment Outcome
Zotarolimus-eluting stents
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Summary:Background: There is limited information regarding the angiographic and clinical outcomes among the different drug-eluting stents (DESs) in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Methods and Results: A total 355 consecutive AMI patients who underwent PCI with a sirolimus- (SES, n=116) or paclitaxel- (PES, n=153) or zotarolimus-eluting stent (ZES, n=86) were enrolled. The 6-month angiographic and 1-year clinical outcomes were compared among the 3 groups. At 6 months, there was a trend toward a higher incidence of binary restenosis in the PES group (SES: 8.6%, PES: 19.8%, ZES: 8.3%, P=0.052). Percentage of restenosis was higher in the PES group compared with SES, but was similar to ZES (SES: 18.75 ±18.16%, PES: 29.32 ±24.16%, ZES: 23.91 ±17.03%, P=0.006). Late loss was lower in the SES group compared with PES and ZES (SES: 0.44 ±0.52, PES: 0.83 ±0.87, ZES: 0.75 ±0.63, P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-08-1086