A Model for all Genomes: The Role of Transcription Factories

A model for all genomes involving one major architectural motif is presented: DNA or chromatin loops are tethered to “factories” through the transcription machinery—a polymerase (active or inactive) or its transcription factors (activators or repressors). These loops appear and disappear as polymera...

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Bibliographic Details
Published in:Journal of molecular biology 2010-01, Vol.395 (1), p.1-10
Main Author: Cook, Peter R.
Format: Article
Language:English
Subjects:
Animals
Bacteria - genetics
Chromatin
chromatin loop
chromosome
DNA
Eukaryota - genetics
Gene Expression Regulation
Genome - genetics
Genomes
Humans
Models, Genetic
Repressors
RNA polymerase
transcription factor
Transcription factors
transcription factory
Transcription, Genetic
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Summary:A model for all genomes involving one major architectural motif is presented: DNA or chromatin loops are tethered to “factories” through the transcription machinery—a polymerase (active or inactive) or its transcription factors (activators or repressors). These loops appear and disappear as polymerases initiate and terminate (and as factors bind and dissociate), so the structure is ever-changing and self-organizing. This model is parsimonious, detailed (and so easily tested), and incorporates elements found in various other models.
ISSN:0022-2836
1089-8638
DOI:10.1016/j.jmb.2009.10.031