L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children

We previously reported an association between relative L-ficolin deficiency and recurrent respiratory infections co-existing with allergic disorders in children. To confirm and extend this preliminary finding, we performed a prospective study on children of a similar age (mean 8.9 years) designed to...

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Bibliographic Details
Published in:Molecular immunology 2009-12, Vol.47 (2-3), p.415-419
Main Authors: Cedzynski, Maciej, Atkinson, Anne P.M., St. Swierzko, Anna, MacDonald, Shirley L., Szala, Agnieszka, Zeman, Krzysztof, Buczylko, Krzysztof, Bak-Romaniszyn, Leokadia, Wiszniewska, Magdalena, Matsushita, Misao, Szemraj, Janusz, Banasik, Małgorzata, Turner, Marc L., Kilpatrick, David C.
Format: Article
Language:English
Subjects:
Adolescent
Allergy
Case-Control Studies
Child
Ficolin-2
Ficolins
Genotype
Humans
Immunodeficiency
Infant
Infection
Innate immunity
L-ficolin
Lectins - blood
Lectins - deficiency
Mannan-binding lectin
Mannose-binding lectin
Mannose-Binding Lectin - blood
Mannose-Binding Lectin - genetics
Mannose-Binding Lectin - immunology
Mannose-Binding Protein-Associated Serine Proteases - genetics
MASP-2
Mutation - genetics
Reference Values
Respiratory Hypersensitivity - blood
Respiratory Hypersensitivity - complications
Respiratory Tract Infections - blood
Respiratory Tract Infections - complications
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Summary:We previously reported an association between relative L-ficolin deficiency and recurrent respiratory infections co-existing with allergic disorders in children. To confirm and extend this preliminary finding, we performed a prospective study on children of a similar age (mean 8.9 years) designed to establish whether the principal relationship was with infection or allergy. Serum L-ficolin values in healthy children were normally distributed with a mean value of 3838ng/ml. L-ficolin concentrations were generally lower in patients with asthma and/or allergic rhinitis with (mean 3413ng/ml; p=0.02) or without (3512ng/ml; p
ISSN:0161-5890
1872-9142
DOI:10.1016/j.molimm.2009.08.028