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L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children
We previously reported an association between relative L-ficolin deficiency and recurrent respiratory infections co-existing with allergic disorders in children. To confirm and extend this preliminary finding, we performed a prospective study on children of a similar age (mean 8.9 years) designed to...
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| Published in: | Molecular immunology 2009-12, Vol.47 (2-3), p.415-419 |
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| container_end_page | 419 |
| container_issue | 2-3 |
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| container_title | Molecular immunology |
| container_volume | 47 |
| creator | Cedzynski, Maciej Atkinson, Anne P.M. St. Swierzko, Anna MacDonald, Shirley L. Szala, Agnieszka Zeman, Krzysztof Buczylko, Krzysztof Bak-Romaniszyn, Leokadia Wiszniewska, Magdalena Matsushita, Misao Szemraj, Janusz Banasik, Małgorzata Turner, Marc L. Kilpatrick, David C. |
| description | We previously reported an association between relative L-ficolin deficiency and recurrent respiratory infections co-existing with allergic disorders in children. To confirm and extend this preliminary finding, we performed a prospective study on children of a similar age (mean 8.9 years) designed to establish whether the principal relationship was with infection or allergy. Serum L-ficolin values in healthy children were normally distributed with a mean value of 3838ng/ml. L-ficolin concentrations were generally lower in patients with asthma and/or allergic rhinitis with (mean 3413ng/ml; p=0.02) or without (3512ng/ml; p |
| doi_str_mv | 10.1016/j.molimm.2009.08.028 |
| format | article |
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To confirm and extend this preliminary finding, we performed a prospective study on children of a similar age (mean 8.9 years) designed to establish whether the principal relationship was with infection or allergy. Serum L-ficolin values in healthy children were normally distributed with a mean value of 3838ng/ml. L-ficolin concentrations were generally lower in patients with asthma and/or allergic rhinitis with (mean 3413ng/ml; p=0.02) or without (3512ng/ml; p<0.07) respiratory infections, but not in patients with respiratory infections without allergic disease (3623ng/ml; p=0.2). The lower average values in the group comprised of children with respiratory allergy and infections were largely due to a high proportion of very low values: 18.3% had values below 2150ng/ml compared to only 5.5% of healthy controls (OR=3.9; p=0.01). This relationship was not apparent in the groups characterized by allergy without infection or infections without allergy. An association between mannan-binding lectin (MBL) insufficiency and recurrent respiratory infections was also confirmed. One of the patients was MASP-2 deficient, evidenced both by MASP2 genotyping and by lectin pathway activity measurement. In conclusion, L-ficolin may confer some protection from microorganisms that exacerbate allergic inflammation in the lung and its relative deficiency may contribute to enhanced susceptibility to respiratory infections. MBL insufficiency and MASP-2 deficiency are risk factors for recurrence of infections independently of allergic disease.</description><identifier>ISSN: 0161-5890</identifier><identifier>EISSN: 1872-9142</identifier><identifier>DOI: 10.1016/j.molimm.2009.08.028</identifier><identifier>PMID: 19767106</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Allergy ; Case-Control Studies ; Child ; Ficolin-2 ; Ficolins ; Genotype ; Humans ; Immunodeficiency ; Infant ; Infection ; Innate immunity ; L-ficolin ; Lectins - blood ; Lectins - deficiency ; Mannan-binding lectin ; Mannose-binding lectin ; Mannose-Binding Lectin - blood ; Mannose-Binding Lectin - genetics ; Mannose-Binding Lectin - immunology ; Mannose-Binding Protein-Associated Serine Proteases - genetics ; MASP-2 ; Mutation - genetics ; Reference Values ; Respiratory Hypersensitivity - blood ; Respiratory Hypersensitivity - complications ; Respiratory Tract Infections - blood ; Respiratory Tract Infections - complications</subject><ispartof>Molecular immunology, 2009-12, Vol.47 (2-3), p.415-419</ispartof><rights>2009 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-cc251a5ea60d7d32da1f6263e07ac7446be8407aeafcde1f3d100af288cbcdee3</citedby><cites>FETCH-LOGICAL-c392t-cc251a5ea60d7d32da1f6263e07ac7446be8407aeafcde1f3d100af288cbcdee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19767106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cedzynski, Maciej</creatorcontrib><creatorcontrib>Atkinson, Anne P.M.</creatorcontrib><creatorcontrib>St. Swierzko, Anna</creatorcontrib><creatorcontrib>MacDonald, Shirley L.</creatorcontrib><creatorcontrib>Szala, Agnieszka</creatorcontrib><creatorcontrib>Zeman, Krzysztof</creatorcontrib><creatorcontrib>Buczylko, Krzysztof</creatorcontrib><creatorcontrib>Bak-Romaniszyn, Leokadia</creatorcontrib><creatorcontrib>Wiszniewska, Magdalena</creatorcontrib><creatorcontrib>Matsushita, Misao</creatorcontrib><creatorcontrib>Szemraj, Janusz</creatorcontrib><creatorcontrib>Banasik, Małgorzata</creatorcontrib><creatorcontrib>Turner, Marc L.</creatorcontrib><creatorcontrib>Kilpatrick, David C.</creatorcontrib><title>L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children</title><title>Molecular immunology</title><addtitle>Mol Immunol</addtitle><description>We previously reported an association between relative L-ficolin deficiency and recurrent respiratory infections co-existing with allergic disorders in children. To confirm and extend this preliminary finding, we performed a prospective study on children of a similar age (mean 8.9 years) designed to establish whether the principal relationship was with infection or allergy. Serum L-ficolin values in healthy children were normally distributed with a mean value of 3838ng/ml. L-ficolin concentrations were generally lower in patients with asthma and/or allergic rhinitis with (mean 3413ng/ml; p=0.02) or without (3512ng/ml; p<0.07) respiratory infections, but not in patients with respiratory infections without allergic disease (3623ng/ml; p=0.2). The lower average values in the group comprised of children with respiratory allergy and infections were largely due to a high proportion of very low values: 18.3% had values below 2150ng/ml compared to only 5.5% of healthy controls (OR=3.9; p=0.01). This relationship was not apparent in the groups characterized by allergy without infection or infections without allergy. An association between mannan-binding lectin (MBL) insufficiency and recurrent respiratory infections was also confirmed. One of the patients was MASP-2 deficient, evidenced both by MASP2 genotyping and by lectin pathway activity measurement. In conclusion, L-ficolin may confer some protection from microorganisms that exacerbate allergic inflammation in the lung and its relative deficiency may contribute to enhanced susceptibility to respiratory infections. MBL insufficiency and MASP-2 deficiency are risk factors for recurrence of infections independently of allergic disease.</description><subject>Adolescent</subject><subject>Allergy</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Ficolin-2</subject><subject>Ficolins</subject><subject>Genotype</subject><subject>Humans</subject><subject>Immunodeficiency</subject><subject>Infant</subject><subject>Infection</subject><subject>Innate immunity</subject><subject>L-ficolin</subject><subject>Lectins - blood</subject><subject>Lectins - deficiency</subject><subject>Mannan-binding lectin</subject><subject>Mannose-binding lectin</subject><subject>Mannose-Binding Lectin - blood</subject><subject>Mannose-Binding Lectin - genetics</subject><subject>Mannose-Binding Lectin - immunology</subject><subject>Mannose-Binding Protein-Associated Serine Proteases - genetics</subject><subject>MASP-2</subject><subject>Mutation - genetics</subject><subject>Reference Values</subject><subject>Respiratory Hypersensitivity - blood</subject><subject>Respiratory Hypersensitivity - complications</subject><subject>Respiratory Tract Infections - blood</subject><subject>Respiratory Tract Infections - complications</subject><issn>0161-5890</issn><issn>1872-9142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kctu2zAQRYmiQew8_qAouGqahdQhJVHSpkARNE0AA9mka4Imh80Yerik1MB_Hzo20J1XnCHP3CHuZeyTgFyAUN82eT921Pe5BGhzaHKQzQe2FE0ts1aU8iNbJkxkVdPCgl3EuAEABao6ZwvR1qoWoJbsdZV5sklo4F-PRSZvOQ1x9qknHOyOU-QmxtGSmdDxV5peuB37NQ2pM12H4Q9ZbgaXxjzaicY58oBxS8FMY9hxRxFNxPTM7Qt1LuBwxc686SJeH89L9vv-5_PdQ7Z6-vV492OV2aKVU2atrISp0ChwtSukM8IrqQqE2ti6LNUamzLVaLx1KHzhBIDxsmnsOl1gccluDrrbMP6dMU66p2ix68yA6Zu6LspkUqVkIr-cJKUQtVDtHiwPoA1jjAG93gbqTdhpAXofjd7oQzR6H42GRqdo0tjno_687tH9HzpmkYDvBwCTH_8Ig47v_qOjkFzVbqTTG94AmVSkiA</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Cedzynski, Maciej</creator><creator>Atkinson, Anne P.M.</creator><creator>St. Swierzko, Anna</creator><creator>MacDonald, Shirley L.</creator><creator>Szala, Agnieszka</creator><creator>Zeman, Krzysztof</creator><creator>Buczylko, Krzysztof</creator><creator>Bak-Romaniszyn, Leokadia</creator><creator>Wiszniewska, Magdalena</creator><creator>Matsushita, Misao</creator><creator>Szemraj, Janusz</creator><creator>Banasik, Małgorzata</creator><creator>Turner, Marc L.</creator><creator>Kilpatrick, David C.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200912</creationdate><title>L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children</title><author>Cedzynski, Maciej ; Atkinson, Anne P.M. ; St. Swierzko, Anna ; MacDonald, Shirley L. ; Szala, Agnieszka ; Zeman, Krzysztof ; Buczylko, Krzysztof ; Bak-Romaniszyn, Leokadia ; Wiszniewska, Magdalena ; Matsushita, Misao ; Szemraj, Janusz ; Banasik, Małgorzata ; Turner, Marc L. ; Kilpatrick, David C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-cc251a5ea60d7d32da1f6263e07ac7446be8407aeafcde1f3d100af288cbcdee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Allergy</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Ficolin-2</topic><topic>Ficolins</topic><topic>Genotype</topic><topic>Humans</topic><topic>Immunodeficiency</topic><topic>Infant</topic><topic>Infection</topic><topic>Innate immunity</topic><topic>L-ficolin</topic><topic>Lectins - blood</topic><topic>Lectins - deficiency</topic><topic>Mannan-binding lectin</topic><topic>Mannose-binding lectin</topic><topic>Mannose-Binding Lectin - blood</topic><topic>Mannose-Binding Lectin - genetics</topic><topic>Mannose-Binding Lectin - immunology</topic><topic>Mannose-Binding Protein-Associated Serine Proteases - genetics</topic><topic>MASP-2</topic><topic>Mutation - genetics</topic><topic>Reference Values</topic><topic>Respiratory Hypersensitivity - blood</topic><topic>Respiratory Hypersensitivity - complications</topic><topic>Respiratory Tract Infections - blood</topic><topic>Respiratory Tract Infections - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cedzynski, Maciej</creatorcontrib><creatorcontrib>Atkinson, Anne P.M.</creatorcontrib><creatorcontrib>St. Swierzko, Anna</creatorcontrib><creatorcontrib>MacDonald, Shirley L.</creatorcontrib><creatorcontrib>Szala, Agnieszka</creatorcontrib><creatorcontrib>Zeman, Krzysztof</creatorcontrib><creatorcontrib>Buczylko, Krzysztof</creatorcontrib><creatorcontrib>Bak-Romaniszyn, Leokadia</creatorcontrib><creatorcontrib>Wiszniewska, Magdalena</creatorcontrib><creatorcontrib>Matsushita, Misao</creatorcontrib><creatorcontrib>Szemraj, Janusz</creatorcontrib><creatorcontrib>Banasik, Małgorzata</creatorcontrib><creatorcontrib>Turner, Marc L.</creatorcontrib><creatorcontrib>Kilpatrick, David C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cedzynski, Maciej</au><au>Atkinson, Anne P.M.</au><au>St. Swierzko, Anna</au><au>MacDonald, Shirley L.</au><au>Szala, Agnieszka</au><au>Zeman, Krzysztof</au><au>Buczylko, Krzysztof</au><au>Bak-Romaniszyn, Leokadia</au><au>Wiszniewska, Magdalena</au><au>Matsushita, Misao</au><au>Szemraj, Janusz</au><au>Banasik, Małgorzata</au><au>Turner, Marc L.</au><au>Kilpatrick, David C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children</atitle><jtitle>Molecular immunology</jtitle><addtitle>Mol Immunol</addtitle><date>2009-12</date><risdate>2009</risdate><volume>47</volume><issue>2-3</issue><spage>415</spage><epage>419</epage><pages>415-419</pages><issn>0161-5890</issn><eissn>1872-9142</eissn><abstract>We previously reported an association between relative L-ficolin deficiency and recurrent respiratory infections co-existing with allergic disorders in children. To confirm and extend this preliminary finding, we performed a prospective study on children of a similar age (mean 8.9 years) designed to establish whether the principal relationship was with infection or allergy. Serum L-ficolin values in healthy children were normally distributed with a mean value of 3838ng/ml. L-ficolin concentrations were generally lower in patients with asthma and/or allergic rhinitis with (mean 3413ng/ml; p=0.02) or without (3512ng/ml; p<0.07) respiratory infections, but not in patients with respiratory infections without allergic disease (3623ng/ml; p=0.2). The lower average values in the group comprised of children with respiratory allergy and infections were largely due to a high proportion of very low values: 18.3% had values below 2150ng/ml compared to only 5.5% of healthy controls (OR=3.9; p=0.01). This relationship was not apparent in the groups characterized by allergy without infection or infections without allergy. An association between mannan-binding lectin (MBL) insufficiency and recurrent respiratory infections was also confirmed. One of the patients was MASP-2 deficient, evidenced both by MASP2 genotyping and by lectin pathway activity measurement. In conclusion, L-ficolin may confer some protection from microorganisms that exacerbate allergic inflammation in the lung and its relative deficiency may contribute to enhanced susceptibility to respiratory infections. MBL insufficiency and MASP-2 deficiency are risk factors for recurrence of infections independently of allergic disease.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>19767106</pmid><doi>10.1016/j.molimm.2009.08.028</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Allergy Case-Control Studies Child Ficolin-2 Ficolins Genotype Humans Immunodeficiency Infant Infection Innate immunity L-ficolin Lectins - blood Lectins - deficiency Mannan-binding lectin Mannose-binding lectin Mannose-Binding Lectin - blood Mannose-Binding Lectin - genetics Mannose-Binding Lectin - immunology Mannose-Binding Protein-Associated Serine Proteases - genetics MASP-2 Mutation - genetics Reference Values Respiratory Hypersensitivity - blood Respiratory Hypersensitivity - complications Respiratory Tract Infections - blood Respiratory Tract Infections - complications |
| title | L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children |
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