Brain atrophy and white matter hyperintensities in early Parkinson's disease

The purpose of this research was to examine the extent of global brain atrophy and white matter hyperintensities (WMH) in early Parkinson's disease (PD) compared to normal controls (NC), to explore the relationship between the MRI variables and cognition in PD. In this multicenter study we incl...

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Published in:Movement disorders 2009-11, Vol.24 (15), p.2233-2241
Main Authors: Dalaker, Turi O., Larsen, Jan P., Bergsland, Niels, Beyer, Mona K., Alves, Guido, Dwyer, Michael G., Tysnes, Ole-Bjorn, Benedict, Ralph H.B., Kelemen, Arpad, Bronnick, Kolbjorn, Zivadinov, Robert
Format: Article
Language:English
Subjects:
Aged
Atrophy - complications
Brain - pathology
brain atrophy
Case-Control Studies
cognition
Cohort Studies
Executive Function - physiology
Female
Humans
Imaging, Three-Dimensional - methods
Magnetic Resonance Imaging - methods
Male
Memory - physiology
Mental Status Schedule
Middle Aged
MRI
Multivariate Analysis
Nerve Fibers, Myelinated - pathology
Neuropsychological Tests
Parkinson Disease - pathology
Parkinson Disease - physiopathology
Parkinson's disease
Regression Analysis
SIENAX
Statistics, Nonparametric
white matter hyperintensities
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Summary:The purpose of this research was to examine the extent of global brain atrophy and white matter hyperintensities (WMH) in early Parkinson's disease (PD) compared to normal controls (NC), to explore the relationship between the MRI variables and cognition in PD. In this multicenter study we included 155 PD patients (age 65.6 ± 9.1 years, disease duration 26.7 ± 19.9 months) and 101 age‐matched NC. On 3D‐T1‐WI, we calculated normalized brain volumes using SIENAX software. WMH volumes were assessed semiautomatically. In PD patients, correlation and regression analyses investigated the association between atrophy and WMH outcomes and global, attention‐executive, visuospatial, and memory cognitive functions. Regression analysis was controlled for age, education, depression score, motor severity, cerebrovascular risk, and sex. No significant MRI variable volume group differences were found. The models did not retain any of the imaging variables as significant predictors of cognitive impairment. There was no evidence of brain atrophy or higher WMH volume in PD compared to NC, and MRI volumetric measurements were not significant predictors of cognitive functions in PD patients. We conclude that global structural brain changes are not a major feature in patients with incident PD. © 2009 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.22754