Reiter's syndrome following intravesical bacille bilié de Calmette-Guérin treatment for superficial bladder carcinoma: report of six cases

Abstract We report the cases of six patients who developed acute Reiter's syndrome following intravesical bacille bilié de Calmette-Guérin (BCG) immunotherapy for superficial bladder cancer. After the third to eighth BCG intravesical injection, the patients developed conjunctivitis, aseptic ure...

Full description

Saved in:
Bibliographic Details
Published in:Modern rheumatology 2004-03, Vol.14 (1), p.82-86
Main Authors: Murata, Hideyuki, Adachi, Yoshihiro, Ebitsuka, Takehiko, Chino, Yusuke, Takahashi, Reiko, Hayashi, Taichi, Goto, Daisuke, Matsumoto, Isao, Tsutsumi, Akito, Akaza, Hideyuki, Sumida, Takayuki
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract We report the cases of six patients who developed acute Reiter's syndrome following intravesical bacille bilié de Calmette-Guérin (BCG) immunotherapy for superficial bladder cancer. After the third to eighth BCG intravesical injection, the patients developed conjunctivitis, aseptic urethritis, and polyarthritis consistent with a diagnosis of Reiter's syndrome. HLA-B27 antigen was negative in five of the patients examined. Two of the patients responded to nonsteroidal anti-inflammatory drugs for polyarthritis, and the other four responded to steroids (prednisolone 5-10 mg/day). The frequent use of intracavitary BCG may increase the incidence of BCG-induced Reiter's syndrome. Further analysis of the relationship between HLA-B and -DR alleles and arthritis should shed light on the mechanism of BCG-induced Reiter's syndrome.
ISSN:1439-7595
1439-7609
DOI:10.3109/s10165-003-0272-3