Impact of computerized dosing on eptifibatide-associated bleeding and mortality

Objective The study aimed to determine the impact on eptifibatide-associated bleeding by implementing a computerized dosing algorithm in the cardiac catheterization suite. Background Excessive dosing of eptifibatide is associated with increased bleeding rates and hospital mortality. Although dosing...

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Bibliographic Details
Published in:The American heart journal 2009-12, Vol.158 (6), p.1018-1023
Main Authors: Putney, David R., PharmD, Kleiman, Neal S., MD, Fromm, Robert E., MD, MPH, Buergler, John M., MD
Format: Article
Language:English
Subjects:
Accuracy
Acute coronary syndromes
Age
Algorithms
Cardiovascular
Drug Dosage Calculations
Drug Therapy, Computer-Assisted
Female
Heart attacks
Hemorrhage - chemically induced
Hemorrhage - mortality
Hospitalization
Humans
Intubation
Male
Middle Aged
Mortality
Peptides - administration & dosage
Peptides - adverse effects
Platelet Aggregation Inhibitors - administration & dosage
Platelet Aggregation Inhibitors - adverse effects
Retrospective Studies
Risk factors
Statistical analysis
Studies
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Summary:Objective The study aimed to determine the impact on eptifibatide-associated bleeding by implementing a computerized dosing algorithm in the cardiac catheterization suite. Background Excessive dosing of eptifibatide is associated with increased bleeding rates and hospital mortality. Although dosing adjustments based on renal function has been recommended, its implementation and clinical impact have not been assessed in daily practice. Methods A computerized algorithm was implemented in January 2006 to calculate appropriate eptifibatide infusion dose (1 μg kg−1 min−1 for creatinine clearance
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2009.10.006