Immunogenetic aspects of autism. Review

Autism is a generalized or pervasive developmental disorder that affects about five in ten thousand children worldwide (5/10.000). In Maracaibo the incidence is 1.1/1000, with a ratio of male/female, 4:1. The autistic disorder is defined entirely based on the impairment in three areas: 1) Impairment...

Full description

Saved in:
Bibliographic Details
Published in:Investigación clínica 2009-09, Vol.50 (3), p.393-406
Main Authors: Pardo-Govea, Tatiana, Solís-Añez, Ernesto
Format: Article
Language:Spanish
Subjects:
Animals
Autistic Disorder - epidemiology
Autistic Disorder - etiology
Autistic Disorder - genetics
Autistic Disorder - immunology
Cytokines - blood
Cytokines - immunology
Disease Models, Animal
Female
Food Hypersensitivity
Gene Frequency
Genetic Linkage
Genetic Predisposition to Disease
HLA Antigens - genetics
HLA Antigens - immunology
Humans
Immunogenetic Phenomena
Immunoglobulin E - blood
Immunoglobulin E - immunology
Interleukin-13 Receptor alpha2 Subunit - genetics
Lactoylglutathione Lyase - genetics
Major Histocompatibility Complex
Male
Mice
Mice, Knockout
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins c-met
Receptors, Growth Factor - genetics
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autism is a generalized or pervasive developmental disorder that affects about five in ten thousand children worldwide (5/10.000). In Maracaibo the incidence is 1.1/1000, with a ratio of male/female, 4:1. The autistic disorder is defined entirely based on the impairment in three areas: 1) Impairment of social interaction, 2) Impairment in communication and 3) Stereotyped and repetitive behavior. Autism is a disorder with a large genetic component and a oligogenic inheritance model has been proposed. Quantitative and qualitative disturbances of certain components of the immune system in patients with autism have been used as endophenotype, one of the strategies used to identify candidate genes for susceptibility to autism. On the other hand the hypersensitivity to specific groups of foods such as casein and gluten has become clear, which has led to the postulation of immunogenetics theories in autism, which mainly involve genes of the histocompatibility major complex. Although it has not been confirmed that immunogenetics factors could be involved in the etiopathogenesis of autism, several studies have shown the influence of the complex Human Leucocyte Antigen (HLA) HLA DR4, DR13, DR11, A2 and others genes in the clinical status, risk and therapeutic response of some psychiatric disorders. The lack of literature demands a greater number of studies related to different ethnic groups and the participation of HLA, as well as the importance of this complex in the pathogenesis of psychiatric illness.
ISSN:0535-5133