25-Hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosis

• Published in: Multiple sclerosis 2009-11, Vol.15 (11), p.1280-1285
• Main Authors: Holmøy, Trygve, Moen, Stine Marit, Gundersen, Thomas A, Holick, Michael F, Fainardi, Enrico, Castellazzi, Massimiliano, Casetta, Ilaria
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Brain - pathology; Calcitriol - cerebrospinal fluid; Chromatography, High Pressure Liquid; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Humans; Immunoglobulin G - blood; Inflammation - cerebrospinal fluid; Inflammation - pathology; Magnetic Resonance Imaging; Male; Mass Spectrometry; Medical sciences; Middle Aged; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Multiple Sclerosis, Relapsing-Remitting - cerebrospinal fluid; Multiple Sclerosis, Relapsing-Remitting - pathology; Nervous System Diseases - cerebrospinal fluid; Nervous System Diseases - pathology; Neurology; Recurrence; Seasons; Young Adult
• ISSN: 1352-4585; 1477-0970
• DOI: 10.1177/1352458509107008

Hypovitaminosis D may play a role in multiple sclerosis (MS), but little is known about intrathecal vitamin D. 25-Hydroxyvitamin D was measured in cerebrospinal fluid and sera from 36 patients with relapsing-remitting MS, 20 patients with other inflammatory neurological diseases and 18 patients with non-inflammatory neurological diseases with liquid chromatography-mass spectrometry. There were no significant differences in cerebrospinal fluid concentrations of 25-hydroxyvitamin D, but the cerebrospinal fluid:serum ratio was significantly lower in MS compared with other inflammatory neurological diseases (p=0.0012) and non-inflammatory neurological diseases (p=0.041) patients. The concentrations of 25-hydroxyvitamin D in cerebrospinal fluid and serum were positively correlated and their ratio was similar to that of albumin. Neither the concentrations of 25-hydroxyvitamin D in cerebrospinal fluid or serum nor their ratio were associated with the presence of relapses or gadolinium-enhanced lesions. These results do not support that 25-hydroxyvitamin D is actively transported to the cerebrospinal fluid, or that the cerebrospinal fluid or serum levels or their ratio exert a major impact on MS activity.