The effect of red blood cell age on coagulation

Abstract Background Packed red blood cell (PRBC) units stored and unused at community hospitals are transferred to trauma centers near the end of their shelf storage life, because of a higher likelihood of utilization before expiration without consideration of coagulation system effects. This study...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of surgery 2009-12, Vol.198 (6), p.900-904
Main Authors: Aucar, John A., M.D., M.S.H.I, Isaak, Edan, M.D, Anthony, Douglas, M.D., Ph.D
Format: Article
Language:English
Subjects:
Activated coagulation time
Age
Banking
Biological and medical sciences
Blood cells
Blood Coagulation
Blood Preservation - standards
Blood Preservation - statistics & numerical data
Blood products
Blood transfusion
Citric acid
Clotting
Coagulation
Coagulopathy
Dextrose
Erythrocytes
Experimental study
Expiration
General aspects
Hematologic and hematopoietic diseases
Humans
In vitro methods and tests
Medical sciences
Patients
Phosphates
Plasma
Platelet diseases and coagulopathies
Red blood cells
Storage life
Surgery
Time Factors
Transfusion
Trauma
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Packed red blood cell (PRBC) units stored and unused at community hospitals are transferred to trauma centers near the end of their shelf storage life, because of a higher likelihood of utilization before expiration without consideration of coagulation system effects. This study was conducted to determine if the stored age of PRBC units has an effect on coagulation. Methods Single-donor citrate/phosphate/dextrose–preserved, PRBCs, and fresh frozen plasma (FFP) were recalcified in an in vitro model. The activated clotting time (ACT) was measured using the microsample method on days 3, 19, 20, and 33 from the date of donation. Results The ACT was prolonged as the age of PRBCs increased while other factors were held constant. ACTs on days 19, 20, and 33 were prolonged relative to day 3. Measurements taken on day 33 were significantly prolonged relative to day 20. Conclusions Increasing age of PRBCs measured from the date of donation adversely affects the global coagulation status. This study suggests that we should re-evaluate current blood banking and transfusion practices in trauma care.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2009.05.034