From psychosurgery to neuromodulation: Deep brain stimulation for intractable Tourette syndrome

Tourette syndrome is a neuropsychiatric disorder characterized by motor and vocal tics. It is often associated with depression, obsessive-compulsive symptoms, self-injurious behaviour and attention deficit-hyperactivity disorder (ADHD). In intractable patients, neuromodulation using deep brain stimu...

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Bibliographic Details
Published in:The world journal of biological psychiatry 2009, Vol.10 (4_2), p.366-376
Main Authors: Neuner, Irene, Podoll, Klaus, Janouschek, Hildegard, Michel, Tanja M., Sheldrick, Abigail J., Schneider, Frank
Format: Article
Language:English
Subjects:
Brain - physiopathology
Brain Mapping
Deep brain stimulation
Deep Brain Stimulation - trends
globus pallidus internus
Humans
nucleus accumbens/anterior limb of internal capsule
Psychosurgery - trends
thalamus
Tourette syndrome
Tourette Syndrome - physiopathology
Tourette Syndrome - therapy
Treatment Outcome
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Summary:Tourette syndrome is a neuropsychiatric disorder characterized by motor and vocal tics. It is often associated with depression, obsessive-compulsive symptoms, self-injurious behaviour and attention deficit-hyperactivity disorder (ADHD). In intractable patients, neuromodulation using deep brain stimulation (DBS) has widely replaced psychosurgery. Three different key structures are defined for DBS, the medial portion of the thalamus, the globus pallidus internus and the anterior limb of the internal capsule/nucleus accumbens. This is a comprehensive overview on the effect of DBS on motor and non-motor symptoms using different case series and two larger studies.
ISSN:1562-2975
1814-1412
DOI:10.1080/15622970802513317