Magnetoencephalographic characteristics of psychosis in temporal lobe epilepsy

To test the hypothesis that some particular magnetoencephalographic findings characterize psychosis manifesting in temporal lobe epilepsy (TLE) patients, the authors performed statistical analyses on the correlation between a history of psychosis and four magnetoencephalographic spike-dipole pattern...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 2009, Vol.21 (4), p.455-462
Main Authors: Fukao, Kenjiro, Inoue, Yushi, Yagi, Kazuichi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brain - physiopathology
Brain Mapping
Epilepsy, Temporal Lobe - complications
Epilepsy, Temporal Lobe - physiopathology
Female
Functional Laterality - physiology
Humans
Magnetoencephalography
Male
Middle Aged
Nerve Net - physiopathology
Patient Selection
Psychotic Disorders - complications
Psychotic Disorders - physiopathology
Severity of Illness Index
Online Access:Get full text
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Summary:To test the hypothesis that some particular magnetoencephalographic findings characterize psychosis manifesting in temporal lobe epilepsy (TLE) patients, the authors performed statistical analyses on the correlation between a history of psychosis and four magnetoencephalographic spike-dipole patterns, namely, left and right inferotemporal-horizontal (IH) and superotemporal-vertical (SV) types. Fifty-seven patients with TLE were studied, 16 of whom had a history of psychosis. Of the four types of spike-dipoles, only left SV type showed a strong correlation with psychosis, suggesting that dysfunction of the left temporal neocortex specifically contributes to the manifestation of psychotic symptoms in TLE patients.
ISSN:1545-7222
DOI:10.1176/appi.neuropsych.21.4.455