Malaria Vaccine Development: Current Status

The development of an effective malaria vaccine represents one of the most important approaches that would provide a cost-effective intervention for addition to currently available malaria control strategies. Here, Howard Engers and Tore Godal review recent advances. Over the past decade there has b...

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Bibliographic Details
Published in:Parasitology today (Regular ed.) 1998-02, Vol.14 (2), p.56-64
Main Authors: Engers, H.D., Godal, T.
Format: Article
Language:English
Subjects:
African children
Biological and medical sciences
DNA vaccines
Fundamental and applied biological sciences. Psychology
malaria control
malaria vaccines
novel adjuvants
P. falciparum
peptides
Protozoa
recombinant proteins
Tropical medicine
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
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Summary:The development of an effective malaria vaccine represents one of the most important approaches that would provide a cost-effective intervention for addition to currently available malaria control strategies. Here, Howard Engers and Tore Godal review recent advances. Over the past decade there has been considerable progress in the understanding of immune mechanisms involved in conferring protection to malaria and in the identification of vaccine candidate antigens and their genes. Several new vaccines have entered Phase I/II trials recently, new adjuvants have been developed for human use and new approaches, such as DNA vaccines and structural modification of antigens to circumvent some of the strategies the parasite uses to avoid the immune response, are being applied. Thus, from the TDR perspective, global malaria vaccine development is entering a crucial period with unprecedented opportunities.
ISSN:0169-4758
1873-1473
DOI:10.1016/S0169-4758(97)01184-8