Beneficial effects of N-acetylcysteine in treatment resistant schizophrenia

Poor response to antipsychotics is still an important problem in the treatment of many schizophrenia patients. N-Acetylcysteine (NAC) is a compound that exerts anti-oxidant and scavenging actions against reactive oxygen species. This paper reports a case of poorly responsive schizophrenia patient wh...

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Bibliographic Details
Published in:The world journal of biological psychiatry 2009, Vol.10 (4_2), p.626-628
Main Authors: Bulut, Mahmut, Savas, Haluk Asuman, Altindag, Abdurrahman, Virit, Osman, Dalkilic, Alican
Format: Article
Language:English
Subjects:
Acetylcysteine - adverse effects
Acetylcysteine - therapeutic use
Adult
Antipsychotic Agents - adverse effects
Antipsychotic Agents - therapeutic use
Benzodiazepines - adverse effects
Benzodiazepines - therapeutic use
Clopenthixol - adverse effects
Clopenthixol - analogs & derivatives
Clopenthixol - therapeutic use
Delayed-Action Preparations
Dose-Response Relationship, Drug
Drug Resistance
Drug Therapy, Combination
Female
Free Radical Scavengers - adverse effects
Free Radical Scavengers - therapeutic use
Humans
Psychiatric Status Rating Scales
Schizophrenia - drug therapy
Schizophrenic Psychology
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Summary:Poor response to antipsychotics is still an important problem in the treatment of many schizophrenia patients. N-Acetylcysteine (NAC) is a compound that exerts anti-oxidant and scavenging actions against reactive oxygen species. This paper reports a case of poorly responsive schizophrenia patient who improved considerably with add-on NAC 600 mg/day. The NAC might work through activating cysteine-glutamate antiporters or reducing in nitric oxide (NO) metabolites, free radicals and cytokines or through both of these mechanisms.
ISSN:1562-2975
1814-1412
DOI:10.1080/15622970903144004