A Prospective Study on Correlation between the Decrease in Anti-P17 Antibody Level and Progression to AIDS in Asymptomatic Carriers of HIV

As the majority of human immunodeficiency virus (HIV) carriers are in asymptomatic stage for a long period of time, it is important to investigate the factors or surrogate markers for conversion from asymptomatic to symptomatic stage. Our study is designed to evaluate the relationship among virus is...

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Bibliographic Details
Published in:MICROBIOLOGY and IMMUNOLOGY 1992, Vol.36(8), pp.833-840
Main Authors: Choudhury, Ahmed Murtaza, Yamada, Osamu, Wakamiya, Nobutaka, Kurimura, Takashi
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Acquired Immunodeficiency Syndrome - etiology
Acquired Immunodeficiency Syndrome - immunology
Acquired Immunodeficiency Syndrome - pathology
AIDS/HIV
Biological and medical sciences
Carrier State - immunology
gag Gene Products, Human Immunodeficiency Virus
Gene Products, gag - immunology
Hemophilia A - complications
HIV - isolation & purification
HIV Antibodies - immunology
HIV Antigens - immunology
HIV Seropositivity - immunology
Human immunodeficiency virus
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Medical sciences
Predictive Value of Tests
Prospective Studies
Time Factors
Viral Proteins
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Summary:As the majority of human immunodeficiency virus (HIV) carriers are in asymptomatic stage for a long period of time, it is important to investigate the factors or surrogate markers for conversion from asymptomatic to symptomatic stage. Our study is designed to evaluate the relationship among virus isolation rate, anti-p17 antibody status and progression to AIDS. We studied anti-p17 antibody status along with virus isolation in 56 asymptomatic carriers and 46 AIDS cases. Progression to AIDS was markedly associated with high rate of virus isolation and loss of anti-p17 antibody. In order to know the meaning of loss of anti-p17 antibody during the clinical course, 15 anti-p17 antibody positive and 16 anti-p17 antibody negative cases were followed up prospectively for the development of AIDS. None of the anti-p17 antibody positive cases developed AIDS while 6 out of 16 anti-p17 negative cases developed AIDS during observation period (P
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.1992.tb02085.x