Population-based surveillance for severe rotavirus gastroenteritis in children in Karachi, Pakistan

Abstract The incidence of rotavirus-associated severe diarrhoea and distribution of rotavirus genotypes in children less than five years of age was determined in two low-income communities in Karachi, Pakistan. Over a two-year period, 717 children met eligibility criteria for severe diarrhoea and st...

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Bibliographic Details
Published in:Vaccine 2009-11, Vol.27, p.F25-F30
Main Authors: Qazi, Romena, Sultana, Shazia, Sundar, Shiyam, Warraich, Haider, un-Nisa, Tayyab, Rais, Abida, Zaidi, Anita K.M
Format: Article
Language:English
Subjects:
Allergy and Immunology
Child, Preschool
Cohort Studies
Cost of Illness
Diarrhea - epidemiology
Diarrhea - virology
Female
Gastroenteritis - epidemiology
Gastroenteritis - virology
Genotype
Humans
Incidence
Infant
Male
Pakistan - epidemiology
Population Surveillance
Rotavirus
Rotavirus - genetics
Rotavirus Infections - epidemiology
Surveillance
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Summary:Abstract The incidence of rotavirus-associated severe diarrhoea and distribution of rotavirus genotypes in children less than five years of age was determined in two low-income communities in Karachi, Pakistan. Over a two-year period, 717 children met eligibility criteria for severe diarrhoea and stools were obtained from 575 (80%) with 97 (17%) being rotavirus positive. Adjusted annual rates of severe rotavirus diarrhoea in children less than five years and less than one year were respectively 5.7 and 16.9 per 1000 in community A, and 8.1 and 25.4 per 1000 child years of observation in community B. An estimated 1 in 40 infants experience a severe episode of rotavirus gastroenteritis annually in Pakistan. The most common rotavirus strains were G9P[8] (15%), G1P[8] (13%) and G1[P4] (8.4%). This information will inform policy decisions about the introduction of rotavirus vaccines.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.08.064