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Population-based surveillance for severe rotavirus gastroenteritis in children in Karachi, Pakistan

Abstract The incidence of rotavirus-associated severe diarrhoea and distribution of rotavirus genotypes in children less than five years of age was determined in two low-income communities in Karachi, Pakistan. Over a two-year period, 717 children met eligibility criteria for severe diarrhoea and st...

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Published in:	Vaccine 2009-11, Vol.27, p.F25-F30
Main Authors:	Qazi, Romena, Sultana, Shazia, Sundar, Shiyam, Warraich, Haider, un-Nisa, Tayyab, Rais, Abida, Zaidi, Anita K.M
Format:	Article
Language:	English
Subjects:	Allergy and Immunology Child, Preschool Cohort Studies Cost of Illness Diarrhea - epidemiology Diarrhea - virology Female Gastroenteritis - epidemiology Gastroenteritis - virology Genotype Humans Incidence Infant Male Pakistan - epidemiology Population Surveillance Rotavirus Rotavirus - genetics Rotavirus Infections - epidemiology Surveillance
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creator	Qazi, Romena Sultana, Shazia Sundar, Shiyam Warraich, Haider un-Nisa, Tayyab Rais, Abida Zaidi, Anita K.M
description	Abstract The incidence of rotavirus-associated severe diarrhoea and distribution of rotavirus genotypes in children less than five years of age was determined in two low-income communities in Karachi, Pakistan. Over a two-year period, 717 children met eligibility criteria for severe diarrhoea and stools were obtained from 575 (80%) with 97 (17%) being rotavirus positive. Adjusted annual rates of severe rotavirus diarrhoea in children less than five years and less than one year were respectively 5.7 and 16.9 per 1000 in community A, and 8.1 and 25.4 per 1000 child years of observation in community B. An estimated 1 in 40 infants experience a severe episode of rotavirus gastroenteritis annually in Pakistan. The most common rotavirus strains were G9P[8] (15%), G1P[8] (13%) and G1[P4] (8.4%). This information will inform policy decisions about the introduction of rotavirus vaccines.
doi_str_mv	10.1016/j.vaccine.2009.08.064
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Over a two-year period, 717 children met eligibility criteria for severe diarrhoea and stools were obtained from 575 (80%) with 97 (17%) being rotavirus positive. Adjusted annual rates of severe rotavirus diarrhoea in children less than five years and less than one year were respectively 5.7 and 16.9 per 1000 in community A, and 8.1 and 25.4 per 1000 child years of observation in community B. An estimated 1 in 40 infants experience a severe episode of rotavirus gastroenteritis annually in Pakistan. The most common rotavirus strains were G9P[8] (15%), G1P[8] (13%) and G1[P4] (8.4%). 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subjects	Allergy and Immunology Child, Preschool Cohort Studies Cost of Illness Diarrhea - epidemiology Diarrhea - virology Female Gastroenteritis - epidemiology Gastroenteritis - virology Genotype Humans Incidence Infant Male Pakistan - epidemiology Population Surveillance Rotavirus Rotavirus - genetics Rotavirus Infections - epidemiology Surveillance
title	Population-based surveillance for severe rotavirus gastroenteritis in children in Karachi, Pakistan
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