Monitoring photosensitizer concentration by use of a fiber-optic probe with a small source-detector separation

We present a noninvasive method to track the concentration of photodynamic therapy drugs in real time. The method is based on measurements of backscattered and fluorescent light with a steady-state fluorescence spectrometer. The ratio of the fluorescent light to the scattered light is found to be li...

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Bibliographic Details
Published in:Applied optics (2004) 2000-12, Vol.39 (34), p.6508-6514
Main Authors: Canpolat, M, Mourant, J R
Format: Article
Language:English
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Summary:We present a noninvasive method to track the concentration of photodynamic therapy drugs in real time. The method is based on measurements of backscattered and fluorescent light with a steady-state fluorescence spectrometer. The ratio of the fluorescent light to the scattered light is found to be linearly proportional to the absorption coefficient of the photosensitizer. The fiber-optic probe used for the measurements has a small source-detector separation; therefore the measurements could be performed through the working channel of an endoscope.
ISSN:1559-128X
DOI:10.1364/AO.39.006508