Clostridium difficile infections among Jordanian adult hospitalized patients

This prospective study investigated the important epidemiologic aspects of Clostridium difficile infections (CDIs) among Jordanian adult hospitalized patients. A total of 300 stool specimens were investigated using culture and polymerase chain reaction methods for detection of C difficile , its toxi...

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Bibliographic Details
Published in:American journal of infection control 2009-12, Vol.37 (10), p.864-866
Main Authors: Nasereddin, Lina M., MSc, Bakri, Fares G., MD, Shehabi, Asem A., DSc
Format: Article
Language:English
Subjects:
Adult
Adults
Aged
Anti-Bacterial Agents - pharmacology
antibiotic resistance
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Bacterial Proteins - genetics
Bacterial Toxins - genetics
Bacteriological Techniques
Biological and medical sciences
Clostridium difficile - drug effects
Clostridium difficile - isolation & purification
Clostridium difficile infection
Disease prevention
Enterocolitis, Pseudomembranous - epidemiology
Enterotoxins - genetics
Epidemiology
Epidemiology. Vaccinations
Feces - microbiology
Female
Fluoroquinolones - pharmacology
General aspects
Genes
Hospitals
Human bacterial diseases
Humans
Infection Control
Infectious Disease
Infectious diseases
Jordan
Jordanian patients
Male
Medical sciences
Microbial Sensitivity Tests
Middle Aged
Polymerase Chain Reaction - methods
Prospective Studies
Studies
toxin genes
Toxins
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Summary:This prospective study investigated the important epidemiologic aspects of Clostridium difficile infections (CDIs) among Jordanian adult hospitalized patients. A total of 300 stool specimens were investigated using culture and polymerase chain reaction methods for detection of C difficile , its toxins, and fluoroquinolone resistance. C difficile -positive cultures were found in 13.7% of the patients, and 73% of the isolates carried tcdA and/or tcdB toxin genes, and all C difficile isolates were negative for binary toxin. The isolates showed moderate level of resistance to both ciprofloxacin and levofloxacin, whereas metronidazole and vancomycin were highly susceptible. This study indicates the need for early detection of CDIs and prevention of its severe disease in hospitalized patients.
ISSN:0196-6553
1527-3296
DOI:10.1016/j.ajic.2009.05.001