Bioactive Constituents from Three Vismia Species

Bioassay-guided fractionation of the methanolic extracts of Vismia baccifera, V. jefensis, and V. macrophylla against human breast, CNS, and lung cancer cell lines resulted in the isolation of a new compound, ferruginin C (1), and seven known compounds, ferruginins A (2) and B (3), vismin (4), harun...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2003-06, Vol.66 (6), p.858-860
Main Authors: Hussein, Ahmed A, Bozzi, Berena, Correa, Mireya, Capson, Todd L, Kursar, Thomas A, Coley, Phyllis D, Solis, Pablo N, Gupta, Mahabir P
Format: Article
Language:English
Subjects:
anthraquinones
Anthraquinones - chemistry
Anthraquinones - isolation & purification
Anthraquinones - pharmacology
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
bivismiaquinone
Breast Neoplasms
carbon
cell lines
chemical structure
Clusiaceae
Clusiaceae - chemistry
cytotoxicity
dihydroanthracene
Drug Screening Assays, Antitumor
ferruginina
General pharmacology
Humans
leaves
Lung Neoplasms
Medical sciences
Molecular Structure
Neoplasms, Nerve Tissue
Panama
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytochemicals
plant extracts
Plant Leaves - chemistry
Plants, Medicinal - chemistry
protons
spectral analysis
Tumor Cells, Cultured - drug effects
Vismia
Vismia baccifera
Vismia jefensis
Vismia macrophylla
vismiaquinone
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Summary:Bioassay-guided fractionation of the methanolic extracts of Vismia baccifera, V. jefensis, and V. macrophylla against human breast, CNS, and lung cancer cell lines resulted in the isolation of a new compound, ferruginin C (1), and seven known compounds, ferruginins A (2) and B (3), vismin (4), harunganin (5), vismione B (6), deacetylvismione H (7), and deacetylvismione A (8), as active constituents. In addition, bivismiaquinone (9) and vismiaquinone (10) were obtained as inactive constituents. The structure of ferruginin C was elucidated by spectroscopic means. Compounds 6−8 were the most active, and the cytotoxic activity of compounds 2−5 and 7 is reported for the first time.
ISSN:0163-3864
1520-6025
DOI:10.1021/np020566w