Clinicopathological characteristics of primary gastric T-cell lymphoma

• Published in: Histopathology 2009-12, Vol.55 (6), p.641-653
• Main Authors: Kawamoto, Kenichiro, Nakamura, Shotaro, Iwashita, Akinori, Watanabe, Jiro, Oshiro, Yumi, Nakayama, Yoshifuku, Nimura, Satoshi, Kimura, Nobuhiro, Aoyagi, Kunihiko, Yao, Takashi, Kuramochi, Shigeru, Matsuyama, Atsuji, Kurihara, Kenji, Ohshima, Koichi, Takeshita, Morishige
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Antigens, CD - metabolism; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Biological and medical sciences; Female; Gastric Mucosa - metabolism; Gastric Mucosa - pathology; Genes, T-Cell Receptor gamma - physiology; Helicobacter Infections - pathology; Helicobacter pylori; Helicobacter pylori - isolation & purification; Human bacterial diseases; Humans; Immunohistochemistry; immunophenotype; Immunophenotyping; In Situ Hybridization; Infectious diseases; Investigative techniques, diagnostic techniques (general aspects); Lymphoma, T-Cell, Peripheral - metabolism; Lymphoma, T-Cell, Peripheral - microbiology; Lymphoma, T-Cell, Peripheral - pathology; Male; Medical sciences; Middle Aged; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Proteins - metabolism; RNA-Binding Proteins - metabolism; stomach; Stomach - metabolism; Stomach - microbiology; Stomach - pathology; Stomach Neoplasms - metabolism; Stomach Neoplasms - microbiology; Stomach Neoplasms - pathology; T-cell lymphoma; T-Lymphocytes - pathology
• ISSN: 0309-0167; 1365-2559
• DOI: 10.1111/j.1365-2559.2009.03430.x

Aims:  To investigate the clinicopathological characteristics of 20 primary gastric T‐cell lymphoma (GTCL) cases without human T‐lymphotropic virus type I infection in Japan, a non‐endemic area for coeliac disease. Methods and results:  Fifteen cases had no history of persistent diarrhoea or severe hypoproteinaemia. Histologically, 13 cases (65%) consisted of large cell lymphoma and seven (35%) were of medium‐sized cells. Intraepithelial lymphoma cell invasion was found in three cases (15%). Two of 10 surgical cases (20%) showed intramucosal tumour cell spreading with enteropathy‐like features. Helicobacter pylori CagA gene was detected in three of 10 cases (30%). The lymphoma cells of all 20 cases were positive for CD3 and/or TCRβF1 and negative for CD56. CD4− and CD8− lymphoma was found in 11 cases (55%), CD4+ lymphoma in seven (35%) and CD8+ lymphoma in two (10%). CD30+, CD5+ and CD25+ lymphomas were detected in nine (45%), 10 (50%) and 11 (55%) cases, respectively. Five‐year survival of the 16 available cases was 54%. Early clinical stage and medium‐sized cell lymphoma were significantly (P