Relief of symptoms in patients with group A β-hemolytic streptococcus tonsillopharyngitis: Comparison between telithromycin and penicillin V

• Published in: Scandinavian journal of infectious diseases 2003, Vol.35 (4), p.223-225
• Main Authors: NORRBY, S. Ragnar, CHANG, Joanne, STEWART, John A, BRUMPT, Ivan, CONWAY, Donald P
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - administration & dosage; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Ketolides; Macrolides; Male; Medical sciences; Patient Satisfaction; Penicillin V - administration & dosage; Pharmacology. Drug treatments; Pharyngitis - complications; Pharyngitis - diagnosis; Pharyngitis - drug therapy; Probability; Severity of Illness Index; Streptococcal Infections - diagnosis; Streptococcal Infections - drug therapy; Streptococcus pyogenes - drug effects; Streptococcus pyogenes - isolation & purification; Tonsillitis - complications; Tonsillitis - diagnosis; Tonsillitis - drug therapy; Treatment Outcome
• ISSN: 0036-5548; 1651-1980
• DOI: 10.1080/0036554021000027021

This study compared the resolution of symptoms in patients with group A beta-hemolytic streptococcus tonsillopharyngitis treated with 5 d of telithromycin 800 mg once daily, or 10 d of penicillin V 500 mg 3 times daily. At days 3-5 of treatment, the mean improvement in total symptom score was greater with telithromycin than with penicillin V (p = 0.042). Thus, telithromycin provided faster symptom relief than penicillin V.