Evidence for Sympathetic Origins of Hypertension in Juvenile Offspring of Obese Rats

Maternal obesity in rodents is associated with increased adiposity, impaired glucose tolerance, and hypertension in adult offspring. In this study we investigated the influence of maternal obesity in the rat on blood pressure and blood pressure regulatory pathways in juvenile and adult offspring. Ob...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2010-01, Vol.55 (1), p.76-82
Main Authors: Samuelsson, Anne-Maj, Morris, Abigail, Igosheva, Natalia, Kirk, Shona L, Pombo, Joaquim M.C, Coen, Clive W, Poston, Lucilla, Taylor, Paul D
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Animals, Newborn
Arterial hypertension. Arterial hypotension
Baroreflex
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Body Weight
Cardiology. Vascular system
Dietary Fats - administration & dosage
Experimental diseases
Female
Hypertension - embryology
Hypertension - etiology
Hypertension - physiopathology
Kidney - metabolism
Male
Medical sciences
Norepinephrine - metabolism
Obesity - etiology
Obesity - physiopathology
Peptidyl-Dipeptidase A - blood
Pregnancy
Pregnancy Complications - etiology
Pregnancy Complications - physiopathology
Prenatal Exposure Delayed Effects - etiology
Prenatal Exposure Delayed Effects - physiopathology
Rats
Rats, Sprague-Dawley
Renin - genetics
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sex Factors
Sympathetic Nervous System - physiopathology
Time Factors
Weaning
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Summary:Maternal obesity in rodents is associated with increased adiposity, impaired glucose tolerance, and hypertension in adult offspring. In this study we investigated the influence of maternal obesity in the rat on blood pressure and blood pressure regulatory pathways in juvenile and adult offspring. Obesity was induced before pregnancy in female Sprague-Dawley rats by feeding a highly palatable energy-dense diet. In juvenile animals (30 days of age), before the onset of obesity and hyperleptinemia, basal nighttime mean arterial pressure was significantly raised in the offspring of obese dams (OffOb) relative to offspring of controls (OffCon; mean arterial pressure, malesOffOb, 121.8±0.6 mm Hg versus OffCon, 115.0±0.5 mm Hg, n=6, P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.109.139402