Metal complexes as photochemical nitric oxide precursors: potential applications in the treatment of tumors

The bioregulatory molecule NO plays key roles in cancer biology and has been implicated in both tumor growth and suppression. Furthermore, it is a gamma-radiation sensitizer that may enhance selective killing of neoplastic tissues. For these reasons, there is considerable interest in developing meth...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2009-01 (48), p.10660-10669
Main Authors: Ostrowski, Alexis D, Ford, Peter C
Format: Article
Language:English
Subjects:
Chromium - chemistry
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
Energy Transfer
Fluorescence Resonance Energy Transfer
Humans
Iron - chemistry
Neoplasms - drug therapy
Nitric Oxide - metabolism
Nitroso Compounds - chemistry
Photochemical Processes - radiation effects
Quantum Dots
Radiation-Sensitizing Agents - chemistry
Radiation-Sensitizing Agents - pharmacology
Ruthenium - chemistry
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Summary:The bioregulatory molecule NO plays key roles in cancer biology and has been implicated in both tumor growth and suppression. Furthermore, it is a gamma-radiation sensitizer that may enhance selective killing of neoplastic tissues. For these reasons, there is considerable interest in developing methods for NO delivery to specific physiological targets. In this Perspective, we describe ongoing investigations focused on photochemical methodologies to deliver therapeutic doses of NO to such targets utilizing transition metal complexes that are nitric oxide precursors. The photochemical strategy has the advantages that it allows for precise control of the timing, location, and dosage for the targeted delivery of a bioactive agent.
ISSN:1477-9226
1477-9234
DOI:10.1039/b912898k