Molecular synchronization waves in arrays of allosterically regulated enzymes

Spatiotemporal pattern formation in a product-activated enzymic reaction at high enzyme concentrations is investigated. Stochastic simulations show that catalytic turnover cycles of individual enzymes can become coherent and that complex wave patterns of molecular synchronization can develop. The an...

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Bibliographic Details
Published in:Physical review letters 2007-07, Vol.99 (4), p.048301-048301, Article 048301
Main Authors: Casagrande, Vanessa, Togashi, Yuichi, Mikhailov, Alexander S
Format: Article
Language:English
Subjects:
Catalysis
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Summary:Spatiotemporal pattern formation in a product-activated enzymic reaction at high enzyme concentrations is investigated. Stochastic simulations show that catalytic turnover cycles of individual enzymes can become coherent and that complex wave patterns of molecular synchronization can develop. The analysis based on the mean-field approximation indicates that the observed patterns result from the presence of Hopf and wave bifurcations in the considered system.
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.99.048301