Particle size of inhaled corticosteroids: Does it matter?

A question with respect to asthma therapy revolves around the issue of whether better efficacy occurs with an ultrafine-particle inhaled corticosteroid because of better lung deposition into the distal airways. This article reviews particle size and delivery devices of different steroids, clinical o...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2009-12, Vol.124 (6), p.S88-S93
Main Authors: Leach, Chet, PhD, Colice, Gene L., MD, Luskin, Allan, MD
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adrenal Cortex Hormones - administration & dosage
Adrenal Cortex Hormones - economics
Adrenal Cortex Hormones - therapeutic use
Allergy and Immunology
Anti-Asthmatic Agents - administration & dosage
Anti-Asthmatic Agents - economics
Anti-Asthmatic Agents - therapeutic use
Asthma
Asthma - drug therapy
Beclomethasone - administration & dosage
Beclomethasone - economics
Beclomethasone - therapeutic use
Biological and medical sciences
clinical outcomes
Clinical Trials as Topic
delivery devices
Delivery. Postpartum. Lactation
Dose-Response Relationship, Drug
Drug dosages
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gynecology. Andrology. Obstetrics
Humans
Immunopathology
Inhaled corticosteroids
Medical sciences
Particle Size
Patients
pharmacoeconomics
Respiratory therapy
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Studies
Treatment Outcome
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Description
Summary:A question with respect to asthma therapy revolves around the issue of whether better efficacy occurs with an ultrafine-particle inhaled corticosteroid because of better lung deposition into the distal airways. This article reviews particle size and delivery devices of different steroids, clinical outcomes of small- versus large-particle steroids, and the issue of pharmacoeconomics.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.09.050