Pregnancy in a woman with polycystic ovary syndrome and myelodysplastic syndrome (in the form of refractory anemia) treated with allogeneic hemopoietic stem-cell transplantation (alloHSCT)

The case of a 21-year-old patient is presented who was diagnosed simultaneously with myelodysplastic syndrome (MDS) in the form of refractory anemia and hormonal disturbances consistent with polycystic ovary syndrome (PCOS). The patient became pregnant 28 months after megachemotherapy and alloHSCT a...

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Bibliographic Details
Published in:Gynecological endocrinology 2010-02, Vol.26 (2), p.135-138
Main Authors: Usnarska-Zubkiewicz, Lidia, Bolanowski, Marek, Zubkiewicz-Kucharska, Agnieszka, Podolak-Dawidziak, Maria, Kuliczkowski, Kazimierz
Format: Article
Language:English
Subjects:
Anemia, Refractory - physiopathology
Anemia, Refractory - therapy
Antineoplastic Agents - therapeutic use
Female
Hematopoietic Stem Cell Transplantation - methods
Hematopoietic Stem Cell Transplantation - standards
Humans
Male
myelodysplastic syndrome
polycystic ovary syndrome
Polycystic Ovary Syndrome - physiopathology
Polycystic Ovary Syndrome - therapy
Pregnancy
Pregnancy Complications, Neoplastic - physiopathology
refractory anemia
Young Adult
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Summary:The case of a 21-year-old patient is presented who was diagnosed simultaneously with myelodysplastic syndrome (MDS) in the form of refractory anemia and hormonal disturbances consistent with polycystic ovary syndrome (PCOS). The patient became pregnant 28 months after megachemotherapy and alloHSCT and delivered a healthy son. The patient's fertility was jeopardized due to both hormonal disturbances and megachemotherapy with cyclophosphamide and allogeneic transplantation; however, her age and body mass reduction in the peritransplant period were beneficial factors. Despite an autologous reconstitution after megachemotherapy and alloHSCT, the malignant neoplastic clone was eliminated and 5 years after transplant the patient remains free from the symptoms of MDS. Two years after the delivery her hormonal findings, including testosterone level, are within the norm, but menstrual bleeding remains irregular and there was a relapse of obesity. To the authors' knowledge, this is the first known case of pregnancy in a patient suffering from MDS and PCOS after HSCT from a sibling donor.
ISSN:0951-3590
1473-0766
DOI:10.3109/09513590903215474