Relationship between body habitus and joint leptin levels in a knee osteoarthritis population

Synovial fluid (SF) leptin has been shown to have an association with cartilage degeneration. Our objective was to examine the relationship between different measures of body habitus and SF leptin levels in an end‐stage knee osteoarthritis (OA) population. Sixty consecutive patients with knee OA wer...

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Bibliographic Details
Published in:Journal of orthopaedic research 2010-03, Vol.28 (3), p.329-333
Main Authors: Gandhi, Rajiv, Takahashi, Mark, Syed, Khalid, Davey, J. Rod, Mahomed, Nizar N.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Body Mass Index
Female
Humans
knee
Knee Joint - metabolism
leptin
Leptin - metabolism
Linear Models
Male
Middle Aged
obesity
Obesity - complications
Obesity - pathology
osteoarthritis
Osteoarthritis - blood
Osteoarthritis - complications
Osteoarthritis - metabolism
Osteoarthritis - pathology
Sex Factors
Statistics, Nonparametric
Synovial Fluid - metabolism
Waist Circumference
Waist-Hip Ratio
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Summary:Synovial fluid (SF) leptin has been shown to have an association with cartilage degeneration. Our objective was to examine the relationship between different measures of body habitus and SF leptin levels in an end‐stage knee osteoarthritis (OA) population. Sixty consecutive patients with knee OA were surveyed prior to surgery for demographic data. Body habitus was assessed with the body mass index (BMI), waist circumference (WC), and waist–hip ratio (WHR). SF and serum samples were analyzed for leptin and adiponectin using specific ELISA. Nonparametric correlations and linear regression modeling was used to identify the relationship between the measures of body habitus and SF leptin levels. Females had greater levels of leptin than males in both the serum and SF. Significant correlations were found between SF leptin levels and BMI and WC (R2 0.44 and 0.38, respectively; p 
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.21000