Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model

The purpose of this study was to investigate whether supraspinatus tendon failure stress at the footprint can increase by improving the bone density at the rotator cuff footprint in a rat model. Bilateral ovariectomies were performed in twenty‐four 4‐month‐old Sprague‐Dawley rats. Half received bisp...

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Bibliographic Details
Published in:Journal of orthopaedic research 2010-03, Vol.28 (3), p.308-314
Main Authors: Cadet, Edwin R., Vorys, George C., Rahman, Ra'Kerry, Park, Sang-Hyun, Gardner, Thomas R., Lee, Francis Y., Levine, William N., Bigliani, Louis U., Ahmad, Christopher S.
Format: Article
Language:English
Subjects:
Animals
Biomechanical Phenomena
Bone Density - drug effects
Bone Density Conservation Agents - pharmacology
Diphosphonates - pharmacology
failure stress
Female
footprint
Humerus - diagnostic imaging
Humerus - metabolism
Imidazoles - pharmacology
Organ Size
osteopenia
Ovariectomy
Rats
Rats, Sprague-Dawley
Rotator Cuff
Stress, Mechanical
supraspinatus tendon
Tendons - pathology
Tendons - physiopathology
Tomography, X-Ray Computed - methods
Uterus - pathology
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Summary:The purpose of this study was to investigate whether supraspinatus tendon failure stress at the footprint can increase by improving the bone density at the rotator cuff footprint in a rat model. Bilateral ovariectomies were performed in twenty‐four 4‐month‐old Sprague‐Dawley rats. Half received bisphosphonate (zoledronic acid) and the other half received no treatment (OVX + ZOM and OVX, respectively). Twelve additional rats did not undergo ovariectomy or receive bisphosphonate treatment (CON). All rats were sacrificed at 7 months of age. Quantitative micro‐computed tomography was used to assess bone density in the proximal humerus. A series of stress–relaxation tests were performed to assess stiffness and failure stress of the supraspinatus tendon. Bone density in OVX + ZOM was significantly higher at the rotator cuff footprint when compared to CON and OVX rats (p 
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.20972