In vitro susceptibility testing in fungi: a global perspective on a variety of methods

Candida and Aspergillus species are the most common causes of invasive fungal infections in immunocompromised patients. The introduction of new antifungal agents and recent reports of resistance emerging during treatment have highlighted the need for in vitro susceptibility testing. For some drugs,...

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Bibliographic Details
Published in:Mycoses 2010, Vol.53 (1), p.1-11
Main Authors: Lass-Flörl, Cornelia, Perkhofer, Susanne, Mayr, Astrid
Format: Article
Language:English
Subjects:
Antifungal Agents - pharmacology
Aspergillus
Drug Resistance, Fungal
EUCAST
Fungi - drug effects
Fungi - isolation & purification
Humans
in vitro and in vivo resistance
In vitro antifungal susceptibility testing
Microbial Sensitivity Tests - methods
Mycoses - microbiology
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Summary:Candida and Aspergillus species are the most common causes of invasive fungal infections in immunocompromised patients. The introduction of new antifungal agents and recent reports of resistance emerging during treatment have highlighted the need for in vitro susceptibility testing. For some drugs, there is a supporting in vitro-in vivo correlation available from studies of clinical efficacy. Both intrinsic and emergent antifungal drug resistance are encountered. Various testing procedures have been proposed, including macrodilution and microdilution, agar diffusion, disk diffusion and Etest. Early recognition of infections caused by pathogens that are resistant to one or more antifungals is highly warranted to optimise treatment and patient outcome.
ISSN:0933-7407
1439-0507
DOI:10.1111/j.1439-0507.2009.01813.x