Follicular mucinosis: Clinical, histologic, and molecular remission with minocycline

Follicular mucinosis is an uncommon inflammatory disorder characterized histologically by mucin accumulation in the follicular epithelium. The condition is generally divided into primary and secondary forms, the latter being frequently associated with mycosis fungoides. Lesional skin T-cell clonalit...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2010-01, Vol.62 (1), p.139-141
Main Authors: Parker, Sareeta R.S., MD, Murad, Emma, MD
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Biological and medical sciences
clonality
Clone Cells - pathology
Dermatology
follicular mucinosis
Hair and nails disorders
Humans
Male
Medical sciences
minocycline
Minocycline - administration & dosage
Minocycline - therapeutic use
Mucinosis, Follicular - drug therapy
Mucinosis, Follicular - immunology
Mucinosis, Follicular - pathology
Remission Induction
T-Lymphocytes - immunology
therapy
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Description
Summary:Follicular mucinosis is an uncommon inflammatory disorder characterized histologically by mucin accumulation in the follicular epithelium. The condition is generally divided into primary and secondary forms, the latter being frequently associated with mycosis fungoides. Lesional skin T-cell clonality has been documented in some patients with follicular mucinosis, even those with no histologic evidence of cutaneous lymphoma. In this report, we describe a patient with clonal idiopathic primary follicular mucinosis who had complete clinical, histologic, and molecular remission with minocycline therapy.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2009.01.031