Antibody Response to Oral Streptococci in Behçet's Disease

The serum antibody titers against oral streptococci were studied by enzyme-linked immunosorbent assay (ELISA) both in patients with Behçet's disease (BD) and control groups. The patients with BD showed significantly higher antibody titers to S. sanguis strains 113-20, 114-23, and 118-1 which we...

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Bibliographic Details
Published in:MICROBIOLOGY and IMMUNOLOGY 1992, Vol.36(8), pp.815-822
Main Authors: Yokota, Kenji, Hayashi, Syunji, Fujii, Nobuhiro, Yoshikawa, Kouji, Kotake, Satoshi, Isogai, Emiko, Ohno, Shigeaki, Araki, Yoshio, Oguma, Keiji
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Antibodies, Bacterial - biosynthesis
Antibody Formation
Antibody production
Antigens, Bacterial - immunology
Antigens, Bacterial - isolation & purification
Behcet Syndrome - immunology
Biological and medical sciences
Blotting, Western
Enzyme-Linked Immunosorbent Assay
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunobiology
Mouth - microbiology
Streptococcus - immunology
Streptococcus sanguis
Syndrome
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Summary:The serum antibody titers against oral streptococci were studied by enzyme-linked immunosorbent assay (ELISA) both in patients with Behçet's disease (BD) and control groups. The patients with BD showed significantly higher antibody titers to S. sanguis strains 113-20, 114-23, and 118-1 which were isolated from patients with BD, in comparison with control groups. Also, the reactions of high-titered sera to the crude cell wall and soluble (or membrane) fractions of the 113-20 strain were observed by western blot test. The sera of the patients with BD demonstrated strong bands of approximately 36kDa, 82kDa, and 87kDa in the crude cell wall fractions, and many bands of 80kDa to 150kDa in the membrane fractions, indicating that these proteins are the ones leading the high antibody titers to this bacterium in the sera of patients with BD.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.1992.tb02083.x