Hereditary thrombophilia and recurrence of ischemic placental disease

Objective We sought to evaluate whether testing for hereditary thrombophilia alone or in combination with second-trimester uterine artery Doppler (UAD) is useful in predicting recurrent complications in patients with previous preeclampsia, placental abruption, or stillbirth. Study Design Between 200...

Full description

Saved in:
Bibliographic Details
Published in:American journal of obstetrics and gynecology 2010, Vol.202 (1), p.54.e1-54.e5
Main Authors: Verspyck, Eric, MD, PhD, Borg, Jeanne-Yvonne, MD, Roman, Horace, MD, PhD, Thobois, Bernard, MD, Pia, Patrick, MD, Marpeau, Loïc, MD, PhD
Format: Article
Language:English
Subjects:
Abruptio Placentae - epidemiology
Adult
adverse pregnancy outcome
Biological and medical sciences
Diseases of mother, fetus and pregnancy
Female
Gestational Age
Gynecology. Andrology. Obstetrics
Hematologic and hematopoietic diseases
Humans
Logistic Models
Medical sciences
Obstetrics and Gynecology
Platelet diseases and coagulopathies
Pre-Eclampsia - epidemiology
Pregnancy
Pregnancy Outcome
Pregnancy. Fetus. Placenta
Prospective Studies
Recurrence
ROC Curve
screening
Stillbirth - epidemiology
subsequent pregnancy
thrombophilia
Thrombophilia - congenital
Thrombophilia - epidemiology
Ultrasonography, Doppler
uterine artery Doppler
Uterus - blood supply
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective We sought to evaluate whether testing for hereditary thrombophilia alone or in combination with second-trimester uterine artery Doppler (UAD) is useful in predicting recurrent complications in patients with previous preeclampsia, placental abruption, or stillbirth. Study Design Between 2001 and 2005, 110 consecutive women were included in the study and received 100 mg of aspirin daily. Adjustment was made for several maternal confounding factors using a logistic regression model. Results After multivariable logistic regression analyses, only abnormal UAD assessment was significantly associated with recurrent complications (odds ratio, 11.2; 95% confidence interval, 3.8–32.6) Combining the results of UAD and the presence of laboratory markers of thrombophilia failed to improve the accuracy of UAD to predict recurrent complications. Conclusion Hereditary thrombophilia testing is not useful in predicting recurrent complications in subsequent pregnancy.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2009.08.019